Fujisawa Pharmaceutical Company, Ltd.

Takashi Manabe

Hiroshi Matsuda

Masaaki Matsuo

Shinji Shigenaga

Ikuo Ueda

Nobukiyo Konishi

Hiroshi Miyake

Youichi Shiokawa

Daijiro Hagiwara

Yousuke Katsura

Kenji Murano

Kazuhiko Take

Tadashi Terasaka

Hidenori Azami

Yoshiteru Eikyu

Hiroyuki Okumura

Junya Ishida

Kazuo Nakai

Norihiro Igari

Hiroshi Sasaki

Naoaki Fujii

This invention relates to piperazine derivatives of the formula:wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Aroyl-piperazine derivatives, their preparation and their use as tachykinin antagonists

Piperazine derivatives as tachykinin antagonists

Piperazine derivatives

A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl;

A piperazine compound of the formula: ##STR1## wherein: X is carbonyl or sulfonyl; Y is a direct bond or lower alkylene; and R.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein. The compounds are advantageously used as Tachykinin antagonists in the treatment of respiratory diseases, ophthalmic diseases and inflammatory diseases, for example.

The invention relates to a compound of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen or lower alkyl,

Pyrroloquinoline compounds

The invention relates to novel indolylpiperidine compounds useful in the treatment of allergic disease and inflammation.

Indolylpiperidine compounds, processes for the preparation thereof and

The invention relates to new compounds, of antiallergic activity, of the formula: ##STR1## wherein R.sup.1 is aryl substituted with substituent(s) selected from the group consisting of hydroxy, protected hydroxy, halogen and lower alkoxy, A is lower alkylene, and B is lower alkenylene, or a pharmaceutically acceptable salt thereof.

A thiazole compound of the formula: ##STR1## wherein R.sup.1 is amino or acylamino,

Thiazole compounds and pharmaceutical composition comprising the same

This invention provides a benezene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy substituted by carboxy or protected carboxy, acylamino which may have lower alkyl on the amino moiety, or aryloxy which may have halogen,

Benzene-fused heterocyclic compound and their use as diuretics

A thiazole compound of allergically activity of the formula: ##STR1## wherein R.sup.1 is amino optionally having suitable substituent(s),

Antiallergic thiazole compounds

This invention provides a benzene-fused heterocyclic compound of the formula: ##STR1## wherein R.sup.1 is halogen, nitro, amino, hydroxy, lower alkyl, lower alkoxy or acylamino,

1,4-Dihydro[1]benzothiopyrano[4,3-c]pyrazole derivatives, compositions

Substituted pyrazolo [4,3-c]pyridines and their use as uricosuric,

Pyrimidoisoquinoline/compounds of the formula: ##STR1## where R.sup.1 is H, halogen or lower alkyl, R.sup.2 is NH.sub.2, NO.sub.2 or acylamino and R.sup.3 is carboxy or protected carboxy, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof are disclosed in this application. Also disclosed is a method of treating allergies by administering the compounds of this invention.

Growing community of inventors

Kawanishi, Japan

Takashi Manabe