Mitsubishi Petrochemical Company Limited

Mitsubishi Chemical Industries Limited

Yuka Medias, Co., Ltd.

Sanyo Fine Co., Ltd.

Takashi Kurihara

Sachio Hirose

Eiji Taniyama

Yoshitaka Sako

Hidenari Adachi

Akio Ito

Makiko Shibata

Tammotsu Homma

Junko Hayashi

Takayoshi Asai

Disclosed are a method for testing for the presence of a cytomegalovirus antigen by using an antibody which specifically recognizes cytomegalovirus Lower matrix protein pp65, as a primary antibody, which comprises using an alkaline phosphatase-labeled antibody as a secondary antibody and a method for testing for the presence of a cytomegalovirus antigen which comprises using an alkaline phosphatase-labeled antibody which specifically recognizes cytomegalovirus Lower matrix protein pp65, or (Fab').sub.2 or Fab' fragment of the antibody which specifically recognizes cytomegalovirus Lower matrix protein pp65 as a primary antibody.

Assay method of testing for the presence of cytomegalovirus antigen

There is disclosed a novel .gamma.-carboxyglutamic acid, a method for preparing the same and a method for preparing Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts of these, which comprises introducing .gamma.-carboxyglutamic acid in a peptide synthetic method of human osteocalcin by use of a protected L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof.

Amino acid derivative, method for preparing the same and method for

Gla.sup.17 human osteocalcin and Glu.sup.17 human osteocalcin or salts thereof are prepared by introducing .gamma.-carboxyglutamic acid into the amino acid sequence of said osteocalcin by employing a protective L-.gamma.-carboxyglutamic acid represented by the formula: ##STR1## wherein n represents 0, 1 or 2, or a salt thereof in the appropriate position in the reacting sequence of amino acids which form the osteocalcin.

Y-carboxyglutamate derivative, method for preparing the same and method

There are disclosed a novel polypeptide represented by the formula shown below or its acid addition salt or complex: ##STR1## wherein Ala represents alanine, Ser serine, Leu leucine, Thr threonine, Val valine, Gly glycine, Lys lysine, Gln glutamine, Glu glutamic acid, His histidine, Tyr tyrosine, Pro proline, Arg arginine, Asp aspartic acid, and n represents an integer of 3 to 7, and a process for producing the same comprising forming a peptide or polypeptide represented by the above formula and subjecting the structural units containing a peptide residue represented by the formula: ##STR2## wherein R represents an active ester residue, Ala, Ser, Leu, Thr and n have the same meanings as defined above, formed in any step of the reaction to cyclization reaction.

Novel polypeptide and process for producing the same

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Ibaraki, Japan

Takashi Kurihara