Kao Corporation

Koei Chemical Company, Limited

Takashi Kurahashi

Hirohiko Ishida

Kentaro Kumihashi

Nanao Watanabe

Hideki Kuranishi

Sadao Asahi

To provide a method for objectively evaluating or screening to identify a substance which is capable of suppressing or regulating olfaction. A method of evaluating or screening to identify an agent for suppressing olfactory sensitivity, including adding a test substance to a substrate having a voltage-dependent cation channel and evaluating or selecting a substance that inhibits an electrical activity caused by the cation channel. A method of evaluating or screening to identify an agent for suppressing olfactory sensitivity, including the following steps (1) to (4): (1) adding a test substance to a substrate having a voltage-dependent cation channel; (2) measuring electrical activity caused by the voltage-dependent cation channel; (3) comparing the electrical activity measured in step (2) with the corresponding electrical activity in a control group; and (4) evaluating or selecting the test substance that inhibits the electrical activity as an agent for suppressing olfactory sensitivity, based on the results obtained in step (3).

Method for screening olfactory sensibility inhibitor

Process for preparing N-tert-butyl-2-pyrazinecarboxamide and

Growing community of inventors

Osaka, Japan

Takashi Kurahashi