Toyota Jidosha Kabushiki Kaisha

Nitto-Denko Corporation

Ono Pharmaceutical Co., Ltd.

Brother Kogyo Kabushiki-Kaisha

Toyota Shatai Kabushiki Kaisha

Nippondenso Co., Ltd.

Denso Corporation

Nippon Soken, Inc.

Aisin Seiki Kabushiki Kaisha

Toyota Jidosha Kogyo Kabushiki Kaisha

Denso Ten Limited

Brother Kabushiki Kaisha

Takashi Kondo

Taihei Nishiyama

Sho Kouyama

Chris Yarnold

Osamu Ichihara

Stuart Flanagan

Akira Imagawa

Steve Courtney

Motoyuki Tanaka

Atsushi Hiramatsu

Yasuo Hirooka

Tomoyuki Koda

Hiroyuki Katayama

Masaki Shimizu

Keiji Hashimoto

Yoshikazu Kurono

Fumiaki Asano

Hiroki Kono

Kohichi Akahane

Kenji Ito

Yasunari Ooyabu

Kiyoyuki Uchida

Tatsuo Sugitani

Naoto Kushi

Hirokazu Matsuda

Daisuke Kanno

Yoshihisa Nozaki

Atsushi Ida

Jun Gamano

Koichi Harada

Motonari Nakano

Koichi Akahane

Ryo Suzuki

Kazuhiko Koike

Kazuhiro Fuke

Tomomi Hase

Tomohiko Nakanishi

Hiroki Okabe

Takashi Ozaki

Etsuzo Nomura

Masakazu Tanaka

Hiromi Otsuki

Yoshinori Kadowaki

Kazushi Inoue

Miho Ito

Shingo Nakatani

Gareth Neil Brace

Akihiro Funahashi

Koji Akazawa

Yuki Ebe

Daisuke Tsukahara

Tosiharu Kondo

Akira Nishio

Daisuke Hayashi

Hideki Kubo

Elise Gadouleau

Shuji Kurita

Itaru Shibata

Takenori Yamasaki

John Barker

Anthony Richardson

Amane Mochizuki

Jun Hasegawa

Hiromi Sano

Sheng Li

Shoji Inagaki

Mizuho Sugiyama

Seiji Mizuno

Norishige Konno

Morito Oshita

Yukio Kawai

Takao Tate

Yasuyoshi Sawada

Yamato Yorifuji

Haruyuki Obata

Minoru Yamaguchi

Hiroya Nakaji

Munehisa Mitani

Ryuichi Kimura

Michio Morishita

Naohiro Takeshita

Hyunsik Chae

Takumi Suzawa

Yoshihiro Hara

Tomoyuki Fujita

Yuji Tagawa

Yasuhiko Watanabe

Jesse Dan Froehlich

Fumio Kojima

Yukio Nishida

Jun Shibata

Shigeru Abe

Nobuhisa Nakajima

Yoshihide Sugihara

Yasuo Tagawa

Yoshiaki Kondo

Kiyohiko Mizuno

Toshikazu Takagi

Makoto Aoyama

Hiroshi Adachi

A compound represented by general formula (I) (wherein all symbols are as defined in the description) or a salt, solvate, N-oxide form or prodrug thereof is a potent FXIa inhibitor, has excellent oral absorption properties and kinetics in blood, can exert a potent anti-coagulation activity over a long period of time after being administered orally, and has a discrepancy between the anti-coagulation activity thereof and the CYP-inhibiting activity thereof. Therefore, the compound or the salt, solvate, N-oxide form or prodrug thereof can be used as an efficient prophylactic and/or therapeutic agent for vascular occlusive diseases.

Dihydroindolizinone derivative

The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the substituents are as defined in the description). The compounds of the general formula (I) are inhibitors of factor XIa, and are useful in the prevention of and/or therapy for thromboembolic diseases. 

Substituted pyrrolidines as factor XIa inhibitors for the treatment thromboembolic diseases

A fuel cell includes stacked power cells and an end cell. Each power cell includes a first plate and two first separators sandwiching the first plate. The end cell includes a second plate and two second separators sandwiching the second plate. Through holes formed in each plate and each separator form a power generating gas inlet passage extending in the power cells. The end cell has at least one of a 'first structure,' in which a bottom wall of the through hole of the second plate or an upstream one of the second separators is downwardly recessed compared to corresponding portions of the power cells, and a 'second structure,' in which a bottom wall of the through hole of the second plate or a downstream one of the second separators upwardly projects compared to corresponding portions of the power cells.

Fuel cell

A fuel cell stack includes: a plurality of power generation cells stacked on top of each other; a dummy cell provided on at least one of both ends of the plurality of power generation cells, the dummy cell being configured not to generate electric power; and a reaction gas supply manifold extending through the plurality of power generation cells and the dummy cell. The dummy cell includes one or more dummy cell reaction gas introduction channels as a reaction gas introduction channel that introduces reaction gas from the reaction gas supply manifold to a center area of the dummy cell. At least one of the dummy cell reaction gas introduction channels is provided so as to connect to a bottom face at a lower side of the reaction gas supply manifold in a direction of gravitational force.

Fuel cell stack and dummy cell

A fuel cell stack includes multiple power generating units and a dummy unit, and respectively providing openings providing reactant-gas supply manifolds. Each power generating unit includes one or more first supply passages extending from the opening to a central region thereof. The dummy unit includes one or more second supply passages extending from the opening to a central region thereof, and a second supply passage port at the highest position in the vertical direction among the second supply passage ports where the second supply passages are connected to the opening is located at a lower position in the vertical direction than a first supply passage port at the highest position in the vertical direction among the first supply passage ports where the first supply passages are connected to the opening.

Fuel cell stack

The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases. 

Pyrimidinone and its derivatives inhibiting factor XIa

A fuel cell includes power generation cells and an end cell. Each power generation cell has in it a gas passage, through which power generation gas passes. The fuel cell includes an introducing conduit, which distributes and introduces the power generation gas into the gas passages, and a discharging conduit, which merges flows of the power generation gas after passing through the gas passages and discharges the merged flow. The end cell has in it a bypass passage, which connects the introducing conduit and the discharging conduit to each other. The bypass passage is composed of parallel channels, each of which is independently connected to the introducing conduit. The parallel channels include lower parallel channels and upper parallel channels. The pressure loss in each of the lower parallel channels is smaller than the pressure loss in each of the upper parallel channels.

Fuel cell having end cell with bypass passage

A periphery image display control device displays an image of a periphery area photographed by a camera sensor, and predicts a travel path area which a vehicle-body of the own vehicle will pass through along a predicted travel path. The device detects locations of obstacle points and heights of the obstacle points. The heights of the obstacle points become higher as the obstacle points are farther from the own vehicle. When a gradient (GR=(YO&#x2212;YB)/(XO&#x2212;KB)) being a ratio of 'a subtraction value obtained by subtracting a height of a first obstacle point which is nearer from the own vehicle from a height of a second obstacle point which is farther from the own vehicle' to 'a distance between the two obstacle points along the predicted travel path' is greater than a threshold gradient GRth, the device displays an alert screen for the second obstacle point.

Periphery image display control device

A method of welding comprising contacting a first electrode to a porous body flow path, contacting a second electrode to a plate material, pressing the porous body flow path and the plate material by the first and second electrodes in a thickness direction of the plate material, and spot welding the porous body flow path and the plate material, wherein: a deformation of the plate material in a direction of the second electrode pressing the plate material is smaller than a deformation of the porous body flow path in a direction of the first electrode pressing the porous body flow path.

Method of welding porous body flow path

A fuel cell is formed by laminating a plurality of power generating units. The power generating unit includes: a membrane electrode gas diffusion layer assembly; a sealing portion disposed along its outer circumference; a porous body flow path in which oxidant gas supplied to a cathode-side catalytic layer flows; a shielding plate provided between the sealing portion and the porous body flow path; and first, second separator plates configured to sandwich the membrane electrode gas diffusion layer assembly and the porous body flow path therebetween. The shielding plate, the porous body flow path, and the first separator plate making contact with the porous body flow path project into the oxidant exhaust gas discharge manifold determined by the sealing portion.

Growing community of inventors

Kariya, Japan

Takashi Kondo