Mitsui Toatsu Chemicals, Incorporated

Hoechst Japan Limited

Takashi Kobayashi

Teruyuki Nagata

Yoshitsugu Kono

Akihiro Tamaki

Katsuji Watanabe

Masahiro Sato

Norihiro Tada

Tetsunosuke Shiomura

Kazuo Hagiwara

Tatuo Ooka

Katsuiku Hirokawa

Mikio Shoji

Toru Ikeda

Takeshi Kawarabayashi

Hideo Sadotomo

The invention relates to an animal model of human Alzheimer's disease that is useful for determining the mechanism of the disease and for developing and testing potential therapeutic drugs. More particularly, the present invention relates to the creation of transgenic non-human mammalian animals having integrated into their genome an exogenous DNA construct that encodes a portion of a .beta.-amyloid precursor protein ('APP') and that is designed to overexpress in various types of animal tissues.

Transgenic mouse expressing an .beta.-Amyloid transgene

Transgenic mice carrying a recombinant DNA construct comprising the gene encoding diphtheria toxin A chain operably linked to a osteocalcin promoter. The transgenic mice can be used as a model for metabolic bone diseases since they have decreased bone mass associated with a marked reduction in the number of osteoblasts.

Transgenic mice as a model for metabolic bone diseases

A process for the continuous preparation of aniline by hydrogenating nitrobenzene with hydrogen is disclosed which comprises the steps of suspending, in an aniline solvent, a catalyst of palladium or palladium-platinum which is deposited on a lipophilic carbon having an oil absorbency of at least 100, and carrying out reaction at a temperature of from 150.degree. to 250.degree. C. substantially in the absence of water while aniline and water formed in said reaction are continuously distilled off as vapor from the reaction product, and the concentration of nitrobenzene in the reaction solution is maintained at 0.01% by weight or less, wherein a zinc compound is added to the reaction system as a promotor and carbon monoxide is added to the hydrogen at a concentration of 1-500 ppm.

Process for preparing high-purity aniline

A process for the continuous preparation of aniline by hydrogenating nitrobenzene is disclosed which comprises the steps of suspending, in an aniline solvent, a catalyst of palladium or palladium-platinum which is deposited on a lipophilic carbon having an oil absorbency of at least 100, adding a zinc compound and an alkali metal carbonate or a zinc compound and an alkali metal bicarbonate as promotors to the reaction system, and carrying out reaction at a temperature of from 150 to 250.degree. C. substantially in the absence of water while aniline and water formed in said reaction are continuously distilled off as vapor from the reaction product, and the concentration of nitrobenzene in the reaction solution is maintained at 0.01% by weight or less.

A solution containing atactic polypropylene by-produced during the preparation of a propylene-containing polymer is passed through a tubular, elongated heating zone having a pressure difference of at least 3 kg/cm.sup.2 between its inlet and outlet so that the calculated flow velocity at the outlet is at least 40 m/sec, whereby sticky fine particles of molten atactic polypropylene substantially free of the solvent are formed in suspension in the vaporized solvent. Then, the sticky fine particles are separated from the vaporized solvent.

Method for recovering atactic polypropylene

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Fukuoka, Japan

Takashi Kobayashi