Ube Industries, Inc.

Sankyo Company, Limited

Daiichi Sankyo Company, Limited

Takashi Kobayashi

Takeo Honda

Katsutoshi Fujii

Mikio Kojima

Shigeki Nagai

Kiroku Oda

Tokio Obata

Shinsaku Kobayashi

Shinji Yokoi

Yuji Akiyoshi

Shinjiro Yamamoto

Kazuto Nakagami

Katsuo Kamoshita

Isao Nakayama

Tomio Kimura

Nobuyoshi Iwata

Toshio Sada

Hideakira Tsuji

Keigo Matsumoto

Toshiharu Kamioka

Kanichi Nakamura

Kenji Nishimura, Deceased

The optically active compound (R)-2-amino-1,4-dihydro-6-methyl-4-(3 -nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) ester 5 -isopropyl ester or a pharmacologically acceptable salt thereof, and a method using the compound or its salt to treat circulatory diseases.

Optically active dihydropyridine derivative

Compounds of formula (I): ##STR1## (wherein R.sup.1 and R.sup.2 are hydroxy, alkoxy, aryloxy or acyloxy or R.sup.2 is hydrogen, R.sup.3 is hydrogen or alkyl and R.sup.4 and R.sup.5 are hydrogen or various organic substituents) have valuable antidepressant activity and may be used in the treatment of mental depression.

Cyclopenta[d]pyrimidine derivatives and use as antidepressants

Compounds of formula (I): ##STR1## (in which R.sup.1, R.sup.2 and R.sup.6 represent hydrogen or methyl, R.sup.3 represents methyl or ethyl, R.sup.4 represents an alkyl group or allyl and R.sup.5 represents hydrogen, methyl or chlorine) and acid addition salts thereof have acaricidal and insecticidal activity and may be formulated with suitable carriers or diluents for agricultural, horticultural or domestic use. Processes for the preparation of these compounds are also disclosed.

4-[2-(Di- or trisubstitutedphenoxy)ethyl amino]thienodipyrimidines and

4-Anilinoquinazoline derivatives of formula (I): ##STR1## (in which: R.sup.1 represents a hydrogen atom, a halogen atom, a trifluoromethyl group or a nitro group;

4-Anilinoquinazoline compounds and pharmaceutical compositions thereof

New 4-anilinopyrimidine derivatives of formula (I): ##STR1## (wherein: R.sup.1 and R.sup.2 are the same or different and each represents a C.sub.1 -C.sub.6 alkyl group or R.sup.1 and R.sup.2 together represent a C.sub.3 -C.sub.5 alkylene group;

Pyrimidine derivatives and a pharmaceutical composition containing them

Compounds having the formula (I) ##STR1## [wherein: R.sup.1 and R.sup.2 are each alkyl or halogen, or they are trimethylene or tetramethylene; R.sup.3 is hydrogen or alkyl; A is alkylene; and R.sup.4 is optionally substituted phenyloxy or benzyloxy substituted with at least one alkyl, halogen, alkoxy, alkylthio, alkenyl, trifluoromethyl or nitro; optionally substituted phenyl substituted with one or two halogen atoms, alkyl or alkoxy; furyl or thienyl] and their salts.

Aminopyrimidine derivatives, processes for their preparation, and

A method of using 4-anilinoquinazoline derivatives of formula (I): ##STR1## (in which: R.sup.1 represents a hydrogen atom, a halogen, atom, a trifluoromethyl group or a nitro group;

Method of using 4-anilinoquinazoline derivatives as analgesic and

4-Aminoquinazoline derivatives of formula (I): ##STR1## (wherein: R.sup.1 represents an alkyl group, a cycloalkyl group, an alkenyl group or a benzyl group;

4-Aminoquinazoline derivatives having fungicidal, anti-insect and

Growing community of inventors

Ube, Japan

Takashi Kobayashi