Sankyo Company, Limited

Namiki Seimitsu Houseki Kabushiki Kaisha

Toyota Jidosha Kabushiki Kaisha

Takashi Kasai

Akira Yoshida

Teiichiro Koga

Hiroyuki Koike

Akihiro Watanabe

Kenji Honda

Sadao Ishihara

Ichiro Hayakawa

Hiroshi Kogen

Eiichi Kitazawa

Kozo Oda

Kousei Shimada

Taro Tokui

Katsuhiko Fujimoto

Kazuo Hasegawa

Fujio Saito

Koza Oda

An infusion pump is provided with a slide clamp mechanism having a clamp member for closing or opening an infusion tube and a valve mechanism for pressing the infusion tube to stop flow of a solution in the infusion tube and has a structure where an interlocking mechanism for interlocking the slide clamp mechanism with the valve mechanism only by manipulation of a handle is disposed. During a series of manipulations of the handle, the infusion tube is always closed by one or both of the slide clamp and valvesA andB, so that free flow of a solution in the infusion tubecan be entirely prevented.

Infusion pump

A an infusion tube misfitting detection device for an infusion pump, which can be implemented at a low cost while maintaining safety. When a door unit is to be closed with respect to a pump body in a misloaded state of an infusion tube, a mislead detection inner door is pressed by the infusion tube to operate on a handle lock part provided to a handle. Accordingly, a claw portion of the handle lock part is pushed up, so that the door unit cannot be locked with the pump bodyby inserting the claw portion into a rectangular through-holeof a base plate. Therefore, the misloaded state can be identified.

Tubing misload detection mechanism for an infusion pump

An infusion tube misloading detection mechanism for an infusion pump is provided at a low cost with a safety feature of detecting misloading of infusion tube. When a door unit is to be closed with respect to a pump body in a misloaded state of an infusion tube, a misload detection inner door is pressed by the misloaded infusion tube. Accordingly, an interlock part is prevented from being closed with the pump body. Therefore, the misloaded state can be easily identified.

A compound of a formula (1) or a salt thereof wherein Rrepresents a methyl group. The compound is useful for the preparation of carbapenem-type antibacterial agents.

Compounds for the preparation of carbapenem-type antibacterial agents

A process for the preparation of a carbapenem antibacterial compound of the following formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of the following formula (1) or a salt thereof, and a process for the preparation thereof:wherein Rrepresents a C&#x2013;Calkyl group, Rand Reach independently represents a hydrogen atom or an organic residue or Rand Rtogether with the nitrogen atom they are attached to form a ring.

Processes for the preparation of carbapenem-type antibacterial agents

Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R.sup.3 is alkyl; R.sup.4 is a group of formula (II), (III), (IV), (V), (VI), (VII), (VIII) or (IX): ##STR2## wherein: A.sup.1 is a single bond, alkylene or alkenylene; A.sup.2 is or alkenylene; A.sup.3 is a single bond, alkyleneor alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or various other groups; R.sup.6 is alkyl or phenyl; R.sup.7 is hydrogen or alkyl; R.sup.8 is alkyl or various other groups; and n is 0 and pharmaceutically acceptable salts thereof have valuable inhibitory activity against acyl-CoA: cholesterol acyl transferase.

Urea derivatives having ACAT inhibitory activity, their preparation and

Compounds of formula (I): ##STR1## wherein: R.sup.1 is alkyl; R.sup.2a, R.sup.2b, R.sup.2c and R.sup.2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C.dbd.O)--B.sup.1 (wherein B.sup.1 is hydrogen or alkyl), nitro, --NR.sup.c R.sup.d (wherein R.sup.c is hydrogen or alkyl and Rd is alkyl), hydroxy, protected hydroxy group, alkoxy, cyano, alkylthio, alkylsulfinyl, alkylsulfonyl or halogen; R.sup.3 is alkyl; R.sup.4 is a group of the formula (II) ##STR2## wherein A.sup.1 is a single bond, alkylene or alkenylene; R.sup.5a and R.sup.5b are the same or different and each is hydrogen, alkyl or --A.sup.4 R.sup.5.sub.c wherein A is a single bond, alkylene or alkenylene and R.sup.5.sub.c is alkoxy; and n is 0, and pharmaceutically acceptable salts thereof. Such compounds have valuable inhibitory activity against acyl-CoA (cholesterol acyl transferase).

Amide derivatives having ACAT inhibitory activity, their preparation and

Tricyclic heterocyclic compound

Compounds of formula (I) are provided: ##STR1## wherein: R.sup.1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are hydrogen or various organic groups; and pharmaceutically acceptable salts thereof; as well as methods for the preparation of such compounds and their use in the treatment and prophylaxis of hypercholesteremia and arteriosclerosis.

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Tokyo, Japan

Takashi Kasai