Fujisawa Pharmaceutical Company, Ltd.

Other

Takashi Kamiya

Tsutomu Toyonaka Teraji

Masashi Hashimoto

Teruo Kyoto Oku

Osamu Nakaguti

Yoshiharu Nakai

Kunihiko Tanaka

Yoshihisa Saito

Keiji Hemmi

Kazuo Sakane

Hidekazu Takeno

Takao Takaya

Jiro Goto

Hitoshi Nakamura

Youichi Shiokawa

Hisashi Takasugi

Daijiro Hagiwara

Tadaaki Komori

Masumi Itoh

Yoshihiko Kitaura

Shizuo Maeno

Yoshitaka Inamoto

Masayuki Masumoto

Hiroyuki Takehara

Osamu Nakaguit

Suita Saito

Teruo Oko

Akihito Taniguchi

Osamu Nakagati

A process for preparing a 3-dihalobenzyl-2,4-quinazolinedione derivative represented by the formula (V):

Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives

A process for producing a 2-cephem or 3-cephem derivative compound of the formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted amino radical and R.sub.4 represents hydrogen or a radical selected from the group consisting of carboxy, protected carboxy, ester, acid amide, acid anhydride, acid halide, acid azide and carboxy salt, and the dotted line indicates the alternate bond structure providing 3-cephem or 2-cephem, which comprises:

Disulfide substituted oxazetidine derivatives

The present invention involves certain thiazol-4-yl-acetic acid compounds which are valuable intermediates for the preparation of cephem antibiotics. Said intermediates have the following structure: ##STR1## wherein R.sup.1 is an amino or a protected amino group; R.sup.2 is a group of the formula 13 CONH--R.sup.5 or --NHCO--R.sup.5 wherein R.sup.5 is pyridyl, thiazolyl or an isoxazolyl ring having lower alkyl and halogen substituted phenyl substituents, and A is lower alkylene, or a non-toxic salt thereof.

Thiazolylacetic acid derivative

The present invention relates to new 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutically acceptable salts thereof which have antimicrobial activities and to processes for preparation thereof, to pharmaceutical compositions comprising the same, and to a method of using the same therapeutically in the treatment of infectious diseases in humans and animals. This division relates to intermediate compounds, namely amino or amido-thiazolyl, substituted oxyimino disubstituted acetic acid of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;

Amino thiazole compounds

A novel compound, useful as an intermediate in the production of compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sub.a.sup.1 is hydrogen, amino or a protected amino group,

Pyridinyl and pyrimidinyl derivatives

This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various groups at the fourth position of the azetidinone nucleus, which have antimicrobial activities against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammals including human beings and animals.

Azetidinone compounds and processes for preparation thereof

Antibiotic cephalosporin compounds, method of making and pharmaceutical composition thereof represented by the general formula ##STR1## wherein R.sup.1 is amino, lower alkylamino, a protected amino, a protected lower alkylamino, hydroxy or lower alkoxy,

3,7-Disubstituted-3-cephem-4-carboxylic acid compounds and processes for

Amino or amido-thiazolyl, substituted oxyimino disubstituted acetic acid

This invention relates to new 2-azetidinone compounds, which have antimicrobial activities, and to processes for the preparation thereof, and more particularly, this invention provides new 2-azetidinone compounds, especially ones having various substituted carboxyalkyl radicals at the first position and having various group at the fourth position of the azetidinone nucleus, which have antimicrobial activity against various pathogenic microorganisms and are useful as antibiotics in treatment for microbial infections in mammals including human beings and animals.

2-Azetidinone compounds and processes for preparation thereof

New antimicrobial azetidinone derivatives and their salt of the formula: ##STR1## wherein R.sub.1 amino or acylamino, and A is selected from a variety of groups.

Azetidinone derivatives and process for preparation thereof

3,7-Disubstituted-3-cephem-4-carboxylic acid compounds and pharmaceutical salts thereof having antibacterial properties in the treatment of animals and processes for preparing the compounds.

3,7-Disubstituted-3-cephem-4-carboxylic acid compounds

Azetidinone 4-disulfides

This invention relates to a process for preparing an oxidized penam derivative of the formula: ##STR1## wherein R.sub.1 represents an amino or protected amino radical, and

Process for providing an oxidized penam

This invention relates to novel compounds having antimicrobial activity of the formula ##STR1## in which R.sup.1 is amino or a protected amino group,

Cephem compounds

This invention relates to novel 7-pyrimidinyl and pyridinyl acetamido cephem derivatives of high antibacterial activity.

Growing community of inventors

Suita, Japan

Takashi Kamiya