Kyowa Kirin Co., Ltd.

Nippon Telegraph and Telephone Corporation

Takashi Imaeda

Tetsuya Yamamoto

Kimitaka Endo

Tsutomu Yabuuchi

Ken-ichiro Shimokura

Jouji Nakayama

Ryohei Kawai

Keisuke Yamamoto

Toshimi Kanai

Hideo Ikota

Kei Yoshida

Takuya Murakami

Hiroyuki Ariyama

Tatsuya Miyazawa

Hirohisa Tezuka

Masato Urano

Ken-Ichiro Shimokura

A compound having anticancer activity, or a pharmaceutically acceptable salt thereof is provided. Used is a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: (wherein, Land Lare the same or different and each represents a group represented by one formula selected from the group consisting of formulas (A) to (F), and S represents a group represented by one formula selected from the group consisting of formulas (S1) to (S18)).

Compound with anticancer activity

The present invention provides a double-stranded nucleic acid consisting of a sense-strand nucleic acid and an antisense-strand nucleic acid and comprising a double-strand region having at least 11 base pairs, for suppressing expression of APCS gene, in which an oligonucleotide chain having a chain length of at least 17 nucleotides and at most 30 nucleotides in the antisense-strand nucleic acid is complementary to a target APCS mRNA sequence comprising a base sequence set forth in any one of SEQ ID NOS: 1288 to 1930.

Nucleic acid suppressing expression of APCS

A system management method is disclosed for associating a process object and a process with each node in a tree structure, and operating each node based on the tree structure so as to manage the process object and the process, including: registering a registered user that performs operations for a general node corresponding to the process object or for a function node corresponding to the process; setting the function node as a child node of the general node corresponding to the process object for which the process corresponding to the function node should be performed, and setting the general node as a parent node of the function node; setting registered user operation authority for each registered user; and, when execution of the process corresponding to the function node is requested by the registered user, causing the function node to execute the process only when the process is permitted by the registered user operation authority, of the registered user requesting the process, set in the general node that is a parent node of the function node.

System management method, system management device, system management program, and storage medium containing system management program

A database access control apparatus generates and stores an access key based on a user ID of a user apparatus. Then, the database access control apparatus sends the access key to the user apparatus with an address of a proxy process server apparatus. The user apparatus sends the access key to the proxy process server apparatus when making a database access request, and the proxy process server apparatus sends the access key to the database access control apparatus when making a database process request. When receiving the database process request, the database access control apparatus determines whether an access key same as the access key received from the proxy process server apparatus is stored in the database access control apparatus, and accesses the database only if having the access key.

Database access control method, database access controller, agent processing server, database access control program, and medium recording the program

Growing community of inventors

Tokyo, Japan

Takashi Imaeda