Daiichi Radioisotope Laboratories, Ltd.

Yamagata Technopolis Foundation

Daiitchi Radioisotope Laboratories, Ltd.

Takashi Igarashi

Tetsuo Oi

Hideo Utsumi

Heitaro Obara

Hiroaki Sano

Masaichi Naruse

Kazuhisa Sakurai

Nitroxyl compounds represented by general formula (I) which are usable in acquiring information about active oxygen or in vivo free radicals as biological images such as magnetic resonance images or magnetoencephalograms, wherein A represents hydrogen or &mdash;L&mdash;(CH,),&mdash;OCOR (wherein L represents &mdash;COO&mdash; or -alkylene-COO&mdash;; and R represents C,alkyl); R,, R,, R,, and R,represent each C,alkyl; and n is a number of from 1 to 4. Drugs and reagents containing the above compounds are usable in preventing, treating or diagnosing ischemic diseases, digestive diseases, cancer, cranial nervous diseases accompanied by nerve degeneration, inflammation, cataracts, or drug-induced organopathy.

Nitroxyl compounds and drugs and reagents containing the same as the active ingredient

A medicine or reagent comprising a bipyrazole derivative of the following formula (I), ##STR1## wherein R.sub.1 and R.sub.2 are individually a hydrogen atom, aryl group, alkyl group having 1-5 carbon atoms, or alkoxycarbonylalkyl group having a total of 3-6 carbon atoms, R.sub.3 and R.sub.4 are individually a hydrogen atom, alkyl group having 1-5 carbon atoms, cycloalkyl group having 5-7 carbon atoms, hydroxyalkyl group having 1-3 carbon atoms, benzyl group, naphthyl group, or substituted or unsubstituted phenyl group, as an active component. The medicine is useful for effectively capturing active oxygen and free radicals which cause adult diseases such as cerebral ischemia, heart disease, digestive system disease, and carcinoma, as well as inflammation, and for diagnosing diseases associated with in vivo free radicals.

Bipyrazole derivative, and medicine or reagent comprising the same as

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Togane, Japan

Takashi Igarashi