Stanley Electric Co., Ltd

Astellas Pharma Gmbh

Honda Motor Co., Ltd.

Honda Giken Kogyo Kabushiki Kaisha

Kotobuki Pharmaceutical Co Ltd

Stanley Electric Corporation

Takashi Futami

Teruo Koike

Ryotaro Owada

Takuya Kushimoto

Yasushi Yatsuda

Masafumi Ohno

Yoshifumi Kawaguchi

Takashi Ebisutani

Shinya Omori

Masaaki Muto

Yasuhisa Yaguchi

Takeo Ichihara

Nobutaka Oda

Shuichi Watanabe

Atsushi Suzuki

Tomoyuki Suzuki

Hidetaka Okada

Yuji Tsuchiya

Atsushi Noda

Hiroyuki Moritomo

Tatsuya Kawase

Hiroshi Iwasaki

Hitoshi Taniuchi

Hiroshi Tomiyama

Takuya Matsumaru

Hiroyuki Hisamichi

Kazuhiko Iikubo

Yoshinori Iwai

Ikumi Kuriwaki

Hirotada Kobayashi

Toshiaki Aoki

Shinichiro Gotoh

Makoto Asaumi

Masahito Okamoto

Kazuhisa Tsunoyama

Michio Furukawa

Kazuo Tokuzaki

Kozo Miyasaka

Koji Fukura

Kazuya Makiuchi

Minoru Kameda

Nobuaki Shindou

Masanobu Shinoda

Masahiro Yamagiwa

Tomohiro Tsukada

Yatsushi Yatsuda

Yuichiro Kawamoto

Teruo Koiko

Haruki Okada

Rumi Takeshita

Hideto Hosoda

Ryutaro Ohwada

Provided is a compound useful as a prophylactic and/or therapeutic agent for bladder cancer. As a result of studies on compounds having FGFR inhibitory action, the present inventors have found that the nitrogen-containing aromatic heterocyclic compounds of the present invention have inhibitory action on FGFR1, FGFR2, and/or FGFR3, particularly, mutant FGFR3, and thus, the present invention has been accomplished. The nitrogen-containing aromatic heterocyclic compound of the present invention can be used as a therapeutic agent for various cancers related to FGFR1, FGFR2, and/or FGFR3, such as lung cancer and hormone therapy-resistant breast cancer, stomach cancer, triple negative breast cancer, endometrial cancer, bladder cancer, and glioblastoma, particularly as a prophylactic and/or therapeutic agent for mutant FGFR3-positive bladder cancer.

Nitrogen-containing aromatic heterocyclic compound

[Problem] An object of the present invention is to elucidate a novel genetic mutation which is a cause of cancer, and thereby, to provide a method for detecting the genetic mutation, or a protein which has the mutation, a method for detecting the presence of cancer in a subject, a method for diagnosing cancer in a subject, and a primer set, a probe and a detecting kit for the methods. [Means for Solution] A method for detecting a fibroblast growth factor receptor 4 (FGFR4) mutant in a subject, which comprises a step of detecting the presence of the mutation of glycine at position 183 in a FGFR4 tyrosine kinase domain to cysteine in a sample obtained from the subject.

Method for detecting novel FGFR4 mutant

Disclosed is a vehicle light fitting unit that can include a plurality of light sources, a reflecting plane which diffusely reflects light emitted from the plurality of light sources, and a lens which emits the light, which is diffusely reflected by the reflecting plane, to a front direction. The plurality of light sources can each be provided so that a pitch between one light source and another light source adjacent to the one light source is shorter than a light path length from the one light source to the lens passing through the reflecting plane.

Vehicle light fitting unit with a plurality of light sources

A vehicle light using a projection lens of a novel appearance can provide a feeling of solidness as compared to a simple spherical shape. The vehicle light can include a projection lens having an optical axis and a plurality of separate lens portions divided in a radial pattern with respect to the optical axis of the projection lens. The separate lens portions can have respective light exiting surfaces of different curvatures, and respective light incident surfaces, the shapes of which are determined such that the separate lens portions have the same thickness and the same focal point.

Projection lens for a vehicle light

A vehicle light can include an LED light source disposed such that the optical axis of the LED light source is directed downward, a first lens disposed forward of the LED light source, a second lens disposed below and forward of the first lens, and a first reflector extending from both sides of the LED light source to a position near the optical axis of the LED light source. The first reflector can be configured to reflect light beams from the LED light source toward the first lens so as to form a wide vertically converged and horizontally diffused light distribution pattern. The vehicle light can include a second reflector disposed at a position below and forward of the first reflector. The second reflector can be configured to reflect light beams from the LED light source toward the second lens so as to form a middle-area vertically converged and horizontally diffused light distribution pattern. The lens can be formed by a toroidal lens that is horizontally elongated and that is formed by horizontally extending an aspherical lens cross section having a focus near the LED light source in an arc shape, or by a cylindrical lens having a horizontal focus line. In particular, the lens can be formed by an upper-half lens portion of such a toroidal lens. The vehicle light can include a light shielding shutter having a first upper edge portion and a second upper edge portion lower than the first upper edge portion.

Vehicle light with LED light source

A vehicle light unit can convert an LED light source to a linear light emitting state and can be incorporated into a vehicle light. The vehicle light unit can include a first to fourth lens part in front of an LED light source. The first to third lens parts can convert the point light source or the LED light source into a linear light emitting portion with improved light utilization efficiency by providing first to fourth total reflection surfaces utilizing internal reflection to the third lens part. The light rays through the linear light emitting portion can be incident on the fourth lens part. The fourth lens part can include a plate-shaped light guiding portion with a plurality of total reflection surfaces on one surface and corresponding lens cut portions on the other opposite surface.

Vehicle light unit and vehicle light

An optical lens for use in a vehicle light can be compact and less expensive and has an outer appearance that has a high commercial value and achieves a high light utilization efficiency. The optical lens can include a light incident surface that receives light from a light source and a light output surface to output the light. The light incident surface can include a center light incident surface formed at its center and being convex toward the light source with a plurality of prisms with a polygonal shape formed radially from its center to its periphery. The light output surface can include a toroidal surface corresponding to the center light incident surface and a surrounding light output surface corresponding to the prisms.

Optical lens and vehicle lighting device using the same

A lighting device with a stable high light intensity can effectively dissipate heat generated by an LED so that the light emission efficiency does not deteriorate while the inside temperature distribution can be maintained in an even state. The lighting device can also be configured to prevent snow from adhering onto an outer lens by allowing an outer surface temperature of the lighting device to rise during actuation of the device. The lighting device can also be configured to improve light utilization efficiency. The lighting device can include a semiconductor light emitting device as a light source and can include structure(s) that guides the emission light to a projection lens. The semiconductor light emitting device can be configured to emit light in a reverse or opposed direction with respect to an illumination direction for the lighting device. A projection lens can be disposed in front of the semiconductor light emitting device. An elliptic reflector can be configured to reflect light from the semiconductor light emitting device and to direct the light to the projection lens. A lens holder can be made of metal and the semiconductor light emitting device and the projection lens can be disposed on the lens holder.

Lighting device

Whereas incandescent light bulbs and other similar light sources known in the related art emit light in all directions, LED lamps can emit light in a single direction, and this is manifested in the problem of being unable to achieve light distribution characteristics satisfied by conventional headlamp designs. In accordance with an embodiment of the presently disclosed subject matter, an LED lamp for a light source of a headlamp can include an LED chip in the vicinity of the focus of a projection means and a shielding member covering a portion of the LED chip in a formation allowing a light distribution characteristic suitable for a vehicle front-illumination light to be obtained when light from the LED chip is magnified and projected in an illumination direction by a projection lens or the like constituting the projection means. Accordingly, accurate light distribution characteristics can be obtained in a simple manner by projecting in the illumination direction using the projection lens.

LED lamp for light source

In a vehicle lamp unit that is configured to be mounted on a vehicle, a semiconductor light source can be substantially covered with a first reflector and, therefore, the semiconductor light source is not visually observable (or, is difficult to see) from outside the lamp unit even when a projection lens is disposed in front of the opening of the first reflector and spaced from the first reflector so as not to contact the first reflector. Thus, a vehicle lamp unit having a novel design can be provided in which the projection lens appears as if it is floating in air and in which the semiconductor light source is not visually seen or is difficult to be seen from the outside.

Vehicle lamp unit

A vehicle lamp can include a plurality of light source modules each having an LED as a light source, and optical systems for distributing light from each of the light source modules frontward toward predetermined areas or predetermined patterns that are different from each other and which make up a light distribution pattern. Each of the optical systems can be optimized to emit light to a predetermined area, and each of the light source modules' LEDs can be optimally arranged for each of the corresponding optical systems.

Vehicle lamp

A vehicle lamp can suppress dimensions in the depth direction and provide a large emission area with a simple configuration, and has a light-emitting surface of wraparound configuration with impressive appearance and aesthetic qualities. The vehicle lamp can include a light source unit and a light guide lens. The light source unit can include a light source, and a converting part for converting light from the light source to a narrow width light. The conversion part has an emission area for emitting the converted light. The light guide lens can include one end face having a shape corresponding to the emission area of the conversion part, a thin plate-like light guiding portion for guiding the incident light, and another end face being a farthest part away from the incident surface. The light guide lens guides the incident light toward the other end face and emits the guided light from a predetermined surface thereof as it travels on its way through the lens.

Whereas incandescent light bulbs and other similar light sources known in the related art emit light in all directions, LED lamps can emit light in a single direction, and this is manifested in the problem of being unable to achieve light distribution characteristics satisfied by conventional headlamp designs. In accordance with an embodiment of the disclosed subject matter, an LED lamp for a light source of a headlamp can include an LED chip in the vicinity of the focus of a projection means and a shielding member covering a portion of the LED chip in a formation allowing a light distribution characteristic suitable for a vehicle front-illumination light to be obtained when light from the LED chip is magnified and projected in an illumination direction by a projection lens or the like constituting the projection means. Accordingly, accurate light distribution characteristics can be obtained in a simple manner by projecting in the illumination direction using the projection lens.

LED lamp for light source and method

A projector type vehicle light can provide an improved far distance visibility in a highway mode and other improved headlight performances by switching the low beam distribution and the highway mode light distribution while utilizing AFS functions. The projector type vehicle light can include a first lamp unit and a second lamp unit. The first lamp unit includes a light source, a reflector, a projection lens, and a light-shading member, and is configured to reflect light from the light source by means of the reflector and project light in the forward direction by the projection lens. The second lamp unit can have almost the same configuration as the first lamp unit and is located adjacent to the first lamp unit and either above or below it. The cut-off line formed by the first lamp unit can be located at an angular position below the horizontal line by 0.57 degrees in order to form a low beam distribution for an ordinary road. The cut-off line formed by the second lamp unit can be located at an angular position below the horizontal line by 0.4 or 0.23 degrees in order to form a highway mode light distribution.

Vehicle light

Growing community of inventors

Tokyo, Japan

Takashi Futami