Toray Industries, Inc.

Takashi Endoh

Hiroshi Nagase

Kuniaki Kawamura

Koji Kawai

Toshiaki Tanaka

Jun Hayakawa

Jun Utsumi

Junzo Kamei

Kiyotaka Ohno

Koji Oshima

Atsushi Ohtake

Shu Matsumoto

Hideaki Inada

Shinya Ueno

Kazuhiro Hoshi

Tsutomu Suzuki

Shigeki Itou

Yoshiaki Katsura

Kohei Arakawa

Yuji Negishi

Hideaki Fujii

Remedies for drug addiction

This invention provides an antipuritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphian quaternary ammonium salt derivative and a new morphian-N-oxide derivative which are useful in treating puritus complicated with some diseases.

Antipruritic

A morphinan derivative or its pharmacologically allowed acid addition salt represented with compound I,

Morphinan derivative and its pharmaceutical applications

This invention provides an antipruritc comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Novel morphinan derivatives and pharmaceutically acceptable acid addition salts thereof as compounds having abilities to bind to opioid &egr;-receptor, which have agonist or antagonist activities, are disclosed. The morphinan derivatives according to the present invention are represented by the formula (I).

Morphinane derivatives and medicinal use thereof

A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example,

Morphinan derivatives and pharmaceutical use thereof

This invention provides an antipruritic comprising an opiate &kgr; receptor agonist as an effective component, a new morphinan quaternary ammonium salt derivative and a new morphinan-N-oxide derivative which are useful in treating pruritus complicated with some diseases.

Antipruritic agent

Antitussive agents

An immunosuppressive agent which has low toxicity and which exhibits excellent effectiveness even if it is orally administered is presented. The immunosuppressive agent of the present invention is characterized in that it contains .delta.-opioid antagonist having high selectivity to .delta.-opioid receptor. The present invention also provides a process of producing a naltrindole derivative characterized by reacting naltrexone or a salt thereof with a phenylhydrazine derivative in a solvent in the presence of methanesulfonic acid.

Immunosuppressive agent and process of producing the same

Pharmaceutically useful compounds are 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives which are excellently stable and potent in vivo.

Growing community of inventors

Chigasaki, Japan

Takashi Endoh