Eisai Company, Limited

Takashi Banba

Shizumasa Kijima

Kimio Hamamura

Noriyasu Hirose

Kiiti Ema

Tetsuya Nakamura

Yuichi Inai

Takaharu Nakamura

Hidetoshi Kawashima

Noritoshi Sano

Yukio Narabe

Yoshihiro Hisatake

Kichisaburo Hamamura

Yuko Miyauchi

Yutaka Ohnuki

Yuuichi Inai

2,3,5-trimethyl-benzoquinone is produced by oxidizing 2,3,6-trimethyl-phenol in the presence of a catalyst of cupric chloride and lithium chloride in a solvent mixture of an aromatic hydrocarbon and a lower aliphatic alcohol having 1 to 4 carbon atoms.

Process for preparing 2,3,5-trimethylbenzoquinone

The novel vitamin E derivative provides an excellent antihyperlipemic effect and is defined by the formula (I): ##STR1## wherein R represents a nicotinoyl group; and m is an integer of from 2 to 5 while n is an integer of from 3 to 6, provided that n is larger than m.

Novel vitamin E derivatives and process for the production thereof

A terpene compound having the formula (III) is produced by reacting an allylic halide having the formula (I) with a Grignard reagent having the formula (II) in the presence of anhydrous zinc chloride and a copper compound or an organic zinc halide compound having the formula (IV) in the presence of a copper compound, provided that when A-A is C-C, R' is hydrogen and when A-A is C=C, X is chlorine. ##STR1##

Process for the preparation of terpenes

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Ibaraki, Japan

Takashi Banba