Takeda Chemical Industries, Inc.

Matsushita Electric Co., Ltd.

Takao Yamada

Koichi Kato

Kenji Kawahara

Osamu Nishimura

Tsunehiko Fukuda

Masato Suenaga

Yuri Oshika

Akio Matsumoto

A KiSS-1 peptide or a salt thereof can be produced in a large scale by subjecting a fusion protein or peptide in which a KiSS-1 peptide is ligated to the N-terminal of a protein or peptide having cysteine at the N-terminal, to the reaction of cleaving the peptide bond on the amino acid side of the cysteine residue.

Process for producing kiss-1 peptide

Disclosed are (1) a DNA containing a synthetic gene for expression of human parathyroid hormone represented by the following DNA sequence:

Synthetic gene coding for human parathyroid hormone

A protein of interest or a Met-protein, e.g. the N-Met analog of the protein of the interest can be efficiently separated from a mixture thereof by subjecting the mixture to a separation procedure utilizing the difference in the isoelectric points between the protein and the Met-protein.

Mutual separation of proteins

A protein and a derivative thereof having a methionine residue added at the amino terminus are mutually separated with the utilization of the difference in affinity for hydroxyapatite between them, such as by means of liquid chromatography using a hydroxyapatite column.

A time switch driven by an electric clock motor is disclosed. The time switch has a base plate above which a time dial with on and off-trippers are rotatably mounted. Disposed below the base plate are other components including input and output terminals, switch means electrically connected between the terminals, switch activating means for closing and opening the switch means in accordance with the positions of the on- and off-trippers on the rotating time dial, and gear train leading from a rotor of the motor to the time dial. The motor comprises the rotor which is a bipolarized permanent magnet and an electromagnet in the form of a ring interrupted by a gap in which the rotor is located. In the base plate there is formed a generally annular groove for receiving the electromagnet, such that the electromagnet, a constituent of the motor, is received within the thickness of the base plate to reduce the depth required for the motor disposed below the plate. The components of various kinds to be disposed below the base plate are arranged to be packed together substantially in the same plane parallel to the base plate to reduce the depth required therefor. These space saving structures are combined to reduce the depth or thickness of the whole time switch assembly.

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Osaka, Japan

Takao Yamada