Shionogi Company Limited

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Takao Shishido

Takeshi Noshi

Yoshinori Ando

Steffen Wildum

Barry Clinch

Klaus Kuhlbusch

Kaoru Baba

Takahiro Noda

Jan Michal Nebesky

Aeron C Hurt

Annabelle Lemenuel

Wendy S Barclay

Leo Yi Yang Lee

Jean-Eric Charoin

Ryu Yoshida

Atsuko Yamamoto

Mitsutaka Kitano

Tomokaz Yoshinaga

Annabelle Lemenuel-Diot

Michael J Nebesky

The present invention relates to a method for preventing transmission of influenza, wherein said method comprises administering an effective amount of a compound to a patient having an influenza virus infection, herein referred to as 'index patient', wherein the compound has one of the formulae (I) and (II), or its pharmaceutically acceptable salt. The compound to be used in the present invention reduces infectivity of the influenza virus of the index patient, and therefore, reduces the risk of the index patient to trigger an influenza epidemic or an influenza pandemic as compared to a control patient. Therefore, one aspect of the present invention relates to a method for preventing an influenza epidemic or an influenza pandemic, wherein the method comprises administering an effective amount of a compound to patients having an influenza virus infection (index patients), wherein the compound is administered to at least 10% of all influenza infected persons of a city's or country's population, and wherein the compound has one of the formulae (I) and (II), or is a pharmaceutically acceptable salt thereof.

Compound and method for the prevention of transmission of influenza virus

A medicament characterized in that (A) a compound represented by the formula (I): its pharmaceutically acceptable salt, or a solvate thereof,wherein or the like,is combined with (B) compound(s) having an anti-influenza activity, its pharmaceutically acceptable salt or a solvate thereof and/or an antibody having anti-influenza activity, is useful for treating or preventing influenza.

Medicament for treating influenza characterized by combining a Cap-dependent endonuclease inhibitor and an anti-influenza drug

A screening method for a compound which inhibits a ribonuclease H activity of a reverse transcriptase which includes incubating a substrate with an appropriate primer hybridized to an appropriate template, a metal ion and a reverse transcriptase to form a complex, adding a test substance, and after these steps adding dNTPs to initiate DNA synthesis, measuring the amount of nucleic acid cleaved from the template, and comparing the measured value with a measured value in the absence of a test substance.

Screening method for a ribonuclease H inhibitor of a reverse transcriptase

Growing community of inventors

Osaka, Japan

Takao Shishido