Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Takao Saeki

Yasutaka Takase

Nobuhisa Watanabe

Hironori Ikuta

Shigeru Souda

Hideyuki Adachi

Teiji Kimura

Kazuki Miyazaki

Makoto Matsui

Yasunori Akita

Hisatoshi Mochida

Tadakazu Tokumura

Keigo Tanaka

Osamu Asano

Masashi Ito

Hiroki Ishihara

Toshimi Okada

Daisuke Shinmyo

Hironobu Hiyoshi

Kohtaro Kodama

Nobuyuki Kurusu

Mamoru Yanagimachi

Naoto Ishii

Isao Saito

Yasushi Okamoto

Kenji Hayashi

Hiroshi Tanaka

Kozo Akasaka

Youji Yamagishi

Atsushi Inoue

Hiroyuki Sugumi

Tohru Fujimori

Tadashi Nagakura

Seiji Yoshikawa

Issei Ohtsuka

Kazutomi Kusano

Motoji Kogushi

Manabu Shirato

Masahiro Sakurai

Hisashi Wakita

Takashi Satoh

Mai Saeki, Legal Representative

Tomoko Saeki, Legal Representative

A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, Calkoxy optionally substituted with Calkoxy, or amino optionally substituted with Calkyl.

4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives

An excellent squalene synthase inhibitor is provided. Specifically, what is provided is a compound (I) represented by the following formula, a salt thereof or a hydrate of them. In formula (I), Rrepresents an optionally substituted vinyl group or an aromatic ring which may be substituted. Also, n is an integer of 0 to 2. Further, X, Y and Z are the same as or different from each other and each represents an optionally substituted carbon atom, or an optionally substituted nitrogen atom, sulfur atom or oxygen atom, and Y optionally represents a single bond, and when Y represents the single bond, the ring to which X, Y and Z belong is a 5-membered ring. Also in the formula, CyA represents a 5- to 14 membered non-aromatic cyclic amino group or non-aromatic cyclic amido group which may be substituted, and the non-aromatic cyclic amino group or the non-aromatic cyclic amido group optionally having an oxygen atom or a sulfur atom. Finally, W represents a chain 

N-aryl-substituted cyclic amine derivative and medicine containing the same as active ingredient

Amidino derivatives represented by the following general formula (I):{where X is a group represented by RSONR&#x2014; (wherein Rrepresents optionally substituted Caryl, etc. and Rrepresents hydrogen atom, etc.), etc., Arrepresents 2,6-naphthylene, etc., Rrepresents hydrogen atom, etc. and Y represents carboxyphenyl, etc.}and their pharmacologically acceptable salts or solvates.

Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them

The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same.

Nitrogen-containing heterocyclic compounds and medicaments containing the compounds

Quinuclidine compounds and drugs containing the same as the active ingredient

Nitrogenous heterocyclic derivatives and medicine thereof

The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring; ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent each a hydrogen atom, a halogen atom or a group such as a lower alkoxy group; R.sup.5 represents a group represented by the formula --NR.sup.11 R.sup.12 (wherein R.sup.11 and R.sup.12 represent each a hydrogen atom or a group such as a lower alkyl group) or the like; and R.sup.6 represents a group represented by the formula ##STR2## (wherein R.sup.19 represents a hydrogen atom, a lower alkyl group or the like; R.sup.20, R.sup.21 and R.sup.22 represent each a hydrogen atom, a halogen atom, a hydroxyl group or the like; and r represents 0 or an integer of 1 to 8)!.

Quinazoline derivatives

Nitrogen-containing fused-heterocycle compounds

The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring: ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 R.sup.4, R.sup.5 and R.sup.6 are described herein.

Benzimidazoles for ischemic heart conditions

A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.

Trisubstituted benzene derivatives, composition and methods of treatment

Quinazoline compounds

Anti-ischemic 2,4-diaminoquinazolines

Growing community of inventors

Ibaraki, Japan

Takao Saeki