Chugai Seiyaku Kabushiki Kaisha

Takao Noto

Haruki Ogawa

Hiroshi Okazaki

Yusuke Harada

Minoru Shindo

Isao Matsunaga

Nobuhiro Oi

Teizo Shinozaki

Kanji Moro

Toshiyuki Nebashi

Bunya Aoki

Takao Kimura

Hisao Endo

Kunio Ando

Hiroshi Sasaki

Masahiko Matsumoto

Toshio Kuroki

Yoshiharu Nawata

Hideo Oishi

Kana Kojima

.alpha.-Substituted ureido-benzylpenicillanic acids of the formula ##STR1## (wherein R.sup.1, X and Y are as defined in the description) and pharmaceutically acceptable salts thereof, and a bactericidal composition comprising the above penicillanic acid or the salt and a pharmaceutically acceptable carrier are disclosed. The acids and salts thereof have high antibacterial activities against Gram-positive and Gram-negative bacteria, particularly those of the genus Pseudomonas.

.alpha.-Substituted ureido-benzylpenicillanic acids

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1 R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Cephalosporin derivatives

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Penicillanic acid derivatives which have an excellent antibacterial action particularly against bacteria belonging to family Pseudomonas aeruginosa and are represented by the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 and n are as defined above, and salts thereof; and a process for preparing the same are disclosed.

Penicillanic acid derivatives

A novel antibiotic No. 2-200 represented by the formula ##STR1## which has a broad antimicrobial spectrum and a process for producing the same by cultivating an antibiotic No. 2-200 producing microorganism of the genus Nocardia, and recovering by isolation the antibiotic No. 2-200 accumulated in the culture.

Antibiotic No. 2-200 and process for producing thereof

Growing community of inventors

Machida, Japan

Takao Noto