Shionogi Company Limited

Nisshin Flour Milling Co., Ltd.

Takao Konishi

Koichi Matsumoto

Eiji Kondo

Yoshiyuki Hayashi

Yoshimi Kawamura

Junichi Shoji

Masaru Ogata

Toshio Takahashi

Naoki Tsuji

Akira Murabayashi

Katsuya Tawara

Yasuo Makisumi

Yoshihachi Watanabe

Toshiyuki Kamigauchi

Teruo Hattori

Kosaburo Sato

Kenji Shibata

Nobutake Kimura

Kazuyoshi Kato

Giichi Sugimori

Masaaki Kobayashi

Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria, and stimulate growth of animals.

Glycopetide antibiotic PA-45052-B

An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula: ##STR1## (wherein R.sub.1 is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy) and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.

Anti-mycoplasma agent

An agent for animal growth promotion which comprises, as an essential component, a compound of the formula I: ##STR1## wherein R is ##STR2## or H, or a salt thereof. A method for growth promotion of animals is also provided.

Method for animal growth promotion using glyclopeptides

A vaccine useful for the protection of poultry from colibacillosis infections which comprises as an active ingredient pre-inactivated and ultrasonicated E. coli cells, and a method for protecting poultry from colibacillosis infections which comprises inoculating said vaccine into poultry through cloaca.

Vaccines for fowl colibacillosis

Antibiotics DO-248-A and DO-248-B of the following Formula I: ##STR1## wherein R is ethyl or isopropyl, have antibacterial activity against acid-fast bacteria. DO-248-A, DO-248-B, or their pharmaceutically acceptable salts are, as an active ingredient of anti-fast-acid drugs, orally or parenterally administered to human beings or animal. DO-248-A and DO-248-B are prepared by incubating an antibiotic DO-248-A- and/or DO-248-B-producing microorganism belonging to genus Streptoverticillium in a medium and recovering antibiotic DO-248-A and/or DO-248-B from the culture broth.

Antibiotics DO-248-A and B and process for preparing the same

Novel sulfonamide benzamides which have potent antiviral and anti-coccidial activities with low toxicity and compositions containing them used in prophylaxis or treatment of viral infectious diseases or coccidiosis are provided.

Sulfonamido-benzamide derivatives

New (2-propynylamino)isoxazole and (3-iodo-2-propynylamino)isoxazole derivatives having anti-microbial activity which are used as active ingredients in anti-microbial compositions for medical use, for agricultural use and also for veterinary use.

Iodo propargylaminoisoxazoles as fungicides

Growing community of inventors

Osaka, Japan

Takao Konishi