Ajinomoto Co., Ltd.

Ea Pharma Co., Ltd.

Takao Ikenoue

Seiji Niwa

Nobuo Kondo

Ryusuke Hirama

Akiyo Yamazaki

Toshihiro Hatanaka

Masaru Takayanagi

Yoko Masuzawa

Wataru Miyanaga

Yukio Iino

Satoru Okamoto

Takashi Yamamoto

Hideyuki Tanaka

Naoyuki Fukuchi

Hiroyuki Matsueda

Naoyuki Yamada

Sen Takeshita

Yumiko Fukuda

Fumio Ohta

Naoko Arashida

Koji Ohsumi

Yoko Kageyama

A method of screening a compound having a hypoglycemic effect (hereinafter referred to as 'hypoglycemic compound'), a remedy for diabetes which contains a compound having a novel function mechanism, etc. More specifically speaking, a method of screening a hypoglycemic compound capable of binding to the &#x3b2; subunit of a trimeric GTP-binding protein, a remedy for diabetes comprising a hypoglycemic compound, which is characterized by being capable of binding to the &#x3b2; subunit of a trimeric GTP-binding protein, as the active ingredient, etc.

Remedy for diabetes

The present invention provides a fused polycyclic compound of the following formula, analogues thereof and pharmaceutically acceptable salts thereof; and agents for increasing the sugar-transporting capacity, hypoglycemic agents and pharmaceutical compositions containing the above compounds. This fused polycyclic compound has high medicinal properties and few side-effects, and a therapeutic effect on diabetes. wherein R represents an alkoxy group, R' represents an oxazolylpropionyl group or a thiazolylpropionyl group, and R&#x2033; represent a hydrogen atom.

Fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof

The following fused polycyclic compound, analogues thereof or pharmaceutically acceptable salts thereof have an effect of increasing the sugar-transporting capacity and an effect of lowering the blood glucose level and, therefore, they are useful for preventing and/or treating diabetes and the like. wherein R is a methoxy group, Y is a (2-thiazolyl)-2-ethylcarbonyl group, Rand Rare hydrogen atoms, and Rand Rare methyl groups.

Fused polycyclic compounds

A pharmaceutical composition for preventing and/or treating diabetes, diabetic complication, hyperinsulinemia, disorders of glucose metabolism or obesity, comprising a combination of the following compound, analogues or pharmaceutically acceptable salts thereof with a hypoglycemic agent. 

Therapeutic agents for diabetes

An agent for increasing the sugar-transporting capacity and an agent for preventing and/or treating diabetes, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macroangiopathy, impaired glucose tolerance or adiposis, which contains a lactam compound or a pharmaceutically acceptable salt thereof as the active ingredient.

Lactam compounds and pharmaceutical use thereof

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Kawasaki, Japan

Takao Ikenoue