Nkk Corporation

Takasago International Corporation

Research Development Corporation of Japan

Kanto Kagaku Kabushiki Kaisha

Other

Nippon Kokan Kabushiki Kaisha

Ajinomoto Co., Ltd.

Takeda Pharmaceutical Company Limited

Central Glass Company, Limited

Tokyo Institute of Technology

Japan Science and Technology Corporation

Asahi Kasei Pharma Corporation

Takasago Perfumery Co., Ltd.

Takao Ikariya

Ryoji Noyori

Kunihiko Murata

Masanori Itagaki

Masatsugu Mizuguchi

Masahito Watanabe

Takeshi Ohkuma

Shohei Hashiguchi

Nobuo Seido

Philip Gregory Jessop

Akio Fujii

Kazuhiko Matsumura

Jun Takehara

Sachiko Yamamoto

Osamu Tajima

Makoto Emura

Makoto Miyazawa

Yi Hsiao

Takaaki Toyoda

Itaru Sakai

Nobuyuki Uematsu

Kunisuke Izawa

Susumu Akutagawa

Takashi Ootsuka

Tomoyuki Onishi

Tsutomu Shikada

Takayuki Hamada

Takayoshi Torii

Masami Kozawa

Minoru Asanuma

Hideyuki Ikehira

Makoto Harada

Kunihiko Tsutsumi

Tetsuo Hachiya

Kenzo Sumi

Sadao Yoshikawa

Akira Shiibashi

Tomomichi Nakamura

Masahiko Saburi

Tsutoma Shikada

Asanuma Minoru

Mikoto Iemoto

Hirohito Ooka

Takashi Ohkuma

Youichi Ishii

Takeshi Ota

Toru Yokozawa

Eiji Katayama

Masato Ito

Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H). An extremely practical reduction method can be provided by preferable combinations of the Group 8 (VIII) transition metal complex, the base, a used amount of the base, a pressure of hydrogen gas and a reaction temperature. This method is used in place of hydride reduction and is a useful method by which design of highly active catalysts can be relatively easily made while a high productivity can be expected.

Practical method for reducing esters or lactones

A process for preparing optically active nitro compounds and cyano compounds using a metal complex, which is obtained by reaction of an optically active nitrogen-containing compound and a periodic table group VIII metal complex, in the asymmetric Michael reaction.

Process for preparing optically active nitro compounds and cyano compounds

A highly efficient process is provided for producing an optically active compound having high optical purity by an asymmetric reaction using as a catalyst a transition metal complex having an optically active nitrogen-containing compound as an asymmetric ligand.

Process for producing optically active compound

A method for producing optically active compounds is disclosed. The method is highly practical for producing optically active compounds useful for various utilities such as intermediates for synthesizing pharmaceutical agents, liquid crystal materials and agents for optical resolution.

Method for producing optically active compounds

A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an &#x3b1;-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.

Process for producing optically active halohydrin compound

Ruthenium complexes and process for preparing alcoholic compounds using these

A process for producing an optically active amino alcohol is provided that includes a step in which a nitro ketone or a cyano ketone is reacted with a hydrogen-donating organic or inorganic compound in the presence of a transition metal compound catalyst having an optically active nitrogen-containing compound as an asymmetric ligand to give an optically active nitro alcohol or an optically active cyano alcohol, and a step in which the above optically active alcohol is further reduced to efficiently produce an optically active amino alcohol.

Process for producing optically active amino alcohols and intermediates therefore

Alcohols are produced in a practical and advantageous method, by the hydrogenation of a carbonyl compound under mild conditions, by reacting the carbonyl compounds with hydrogen in the presence of a bipyridyl derivative, a group VIII transition metal complex, and a base, or by reducing a carbonyl compound in the presence of a bipyridyl derivative, a group VIII transition metal complex, a base, and an alcoholic solvent.

Processes for the preparation of alcohols

The invention provides a metal complex comprising a ligand and a metal. The ligand is an aminophosphine compound represented by the following formula (1)

Complexes of transition metals with novel axial asymmetric compounds as the ligands

This document describes a novel and practically excellent process for the preparation of optically active compounds, such as optically active alcohols or amines which are useful for various applications, for example, as synthetic intermediates of pharmaceuticals, liquid crystal materials, and reagents for optical resolution, wherein a hydrogen transfer type asymmetric reduction is carried out in the presence of both a transition metal complex and an optically active nitrogen compound or a transition metal complex having an optically active nitrogen compounds as an asymmetric ligand, and a hydrogen-donating organic or inorganic compound.

Process for preparing optically active compounds

Formic acid or derivatives thereof are produced from non-toxic carbon dioxide in the supercritical state, using it as raw materials, without using solvents, and at a high efficiency owing to a high reaction velocity, by reacting said carbon dioxide and an active hydrogen group-containing compound.

Method for producing formic acid or its derivatives

A process whereby 4-t-butylcyclohexanol with a high content of the cis-isomer, which is useful as a perfume ingredient, can be economically produced on an industrially available scale at a low cost. The process comprises hydrogenating 4-t-butylcyclohexanone by using a specific ruthenium-phosphine complex as a catalyst in the presence of a base containing an alkali metal and an alkylenediamine having from 1 to 6 carbon atoms.

Process for producing cis-4-t-butylcyclohexanol

A novel ruthenium-phosphine complex useful as a catalyst for asymmetric hydrogenation is disclosed, which is represented by formula (I):

Ruthenium-phosphine complex

The present invention provides a method for producing a alcohol including an optically active alcohol by hydrogenating a carbonyl compound in the presence of a homogeneous catalyst, a base and a nitrogen-containing organic compound. Thus, the reaction employs an inexpensive catalyst and proceeds in high yield and high efficiency.

Method for producing an alcohol

Method for producing formic acid of its derivatives

Growing community of inventors

Tokyo, Japan

Takao Ikariya