Kyowa Hakko Kogyo Co., Ltd.

Takao Hatta

Minoru Watanabe

Kenji Muto

Yoshinori Takemoto

Koji Yamada

Nobuhiro Nakamizo

Toru Sugaya

Tamotsu Hashimoto

A vasodilating or anti-hypertensive composition comprises a pharmaceutical carrier and an effective amount of a 1,4-dihydropyridine compound as an active ingredient. The 1,4-dihydropyridine compound may be represented by the following general formula: ##STR1## wherein R'.sub.1 and R'.sub.4 represent a hydrogen atom, R'.sub.2 and R'.sub.3 represent an alkyl group having 1-5 carbon atoms or a substituted heterocyclic group wherein a substituent is an N-benzylpiperidyl group, R'.sub.5 represents a nitro group, and R'.sub.6 and R'.sub.7 represent an alkyl group having 1-5 carbon atoms.

1-Substituted 1,4-dihydropyridines

Compounds having coronary and vasodilator effects, a hypotensive effect, and useful as antianginal drugs and drugs for treating hypertension are represented by the following general formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different groups and each represents a lower alkyl group, one of R.sub.3 and R.sub.4 represents a lower alkyl group and the other represents a group of the general formula: ##STR2## wherein R.sub.5 represents an aralkyl group or an acyl group and n represents 0 or an integer of 1-3; the pharmaceutically acceptable acid addition salts thereof are also effective therapeutic compounds.

1,4-Dihydropyridine derivatives

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Machida, Japan

Takao Hatta