Terumo Kabushiki Kaisha

Other

Takao Anzai

Takayuki Kido

Ichiro Hirahara

Kenichi Shimura

Yuichi Tada

Yoshihiko Abe

Akira Mochizuki

Atsuhiko Nogawa

Satoshi Sawada

Kazuya Omata

Kaori Nishida

Tomoe Hakamatani

Kazushige Ishiura

Kenichi Hamada

Kenji Yokoyama

Hidenori Tanabe

Jun Konishi

Eisuke Sasaki

Norikazu Ishida

Yosuke Kuruma

Yutaro Sonoda

Masanori Kuramoto

Miyuki Shimizu

Naoto Nozawa

Sayaka Shinoda

Yuu Kasori

Atsuo Okumura

Zhe Xu

This invention is to provide a means capable of providing excellent cell proliferation activity to a hydrophilic polymer substrate. Provided is a cell culture substrate comprising a coating layer on at least one surface of a hydrophilic polymer substrate, wherein the coating layer includes a polymer comprising a structural unit derived from furfuryl (meth)acrylate represented by Formula, and a ratio of mass of the polymer contained per unit area of the coating layer is more than 2 μg/cm.

Cell culture substrate

To provide a means capable of providing excellent cell adhesion to a polymer substrate (particularly, a hydrophilic polymer substrate) as compared to the case of performing a surface treatment with polytetrahydrofurfuryl acrylate (PTHFA). Provided is a cell culture substrate comprising a coating layer on at least one side of a polymer substrate, wherein the coating layer includes a copolymer having more than 40% by mole and less than 100% by mole of a structural unit derived from furfuryl (meth)acrylate represented by Formula and more than 0% by mole and less than 60% by mole of a structural unit derived from ethylenically unsaturated monomer having a carboxylic group (the total of the structural unit and the structural unit is 100% by mole).

A method is disclosed for producing an artificial lung including a plurality of porous hollow fiber membranes for gas exchange which have an outer surface, an inner surface forming a lumen, and an opening portion communicating the outer surface with the inner surface. The method includes bringing any of the outer surface and the inner surface into contact with a colloidal solution that contains an antithrombotic high-molecular compound to circulate carbon dioxide gas to a side of the other surface. According to the present disclosure, an artificial lung can be produced in which a coating amount of antithrombotic high-polymer material (an antithrombotic high-molecular compound) on a hollow fiber membrane is increased.

Method for producing artificial lung and artificial lung

To provide a means capable of obtaining further excellent cellular adhesiveness than in a case where a surface of a cell culture substrate (cell culture vessel) is coated using polytetrahydrofurfuryl acrylate (PTHFA). Provided is a cell culture substrate comprising a coating layer on at least one side of a polymer substrate, wherein the coating layer includes a copolymer comprising more than 20% by mole and less than 100% by mole of a structural unit (1) derived from furfuryl (meth)acrylate represented by Formula (1) and more than 0% by mole and less than 80% by mole of a structural unit (2) derived from ethylenically unsaturated monomer having a hydroxyl group (the total of the structural unit (1) and the structural unit (2) is 100% by mole).

Cell culture substrate having a structural unit derived from furfuryl (meth) acrylate

The present invention is to provide a method capable of visualizing a coating state of a protein adsorbent even on a substrate having a complicated structure, in particular, for use on a surface of an apparatus for culturing or growing living cells. The method comprises coating a series of substrates with selected protein adsorbents and fluorescent dye, irradiating selected coated substrates and determining a coating state from color development of the substrates.

Method for coating a cell culture surface

Hollow fiber membranes in an oxygenator for an extracorporeal blood circulator are coated with an antithrombotic polymeric material. The porous hollow fiber membranes for gas exchange have outer surfaces, inner surfaces forming lumens, opening portions through which the outer surfaces communicate with the inner surfaces in a housing. A blood flow path is outside of the hollow fiber membrane bundle in the housing, between a blood inlet port and a blood outlet port. The coating is obtained by filling the blood flow path with a colloidal solution containing an antithrombotic polymeric compound, and moving the colloid solution between the blood inlet port and the blood outlet port for a time that coats a predetermined amount of antithrombotic polymeric compound on the outer surfaces of the hollow fiber membranes. Other surfaces within the oxygenator contacting the blood flow likewise receive the coating.

Oxygenator antithrombotic coating and method of manufacture

This invention is to provide a means capable of obtaining excellent cell proliferation activity without depending on a thickness of a coating layer in a technique of coating a cell culture substrate (cell culture vessel) using a polymer. Provided is a cell culture substrate comprising a coating layer on at least one surface of a polymer substrate, wherein the coating layer includes a copolymer comprising more than 40% by mole and less than 100% by mole of a structural unit (1) derived from carboxyalkyl (meth)acrylate represented by Formula (1) and more than 0% by mole and less than 60% by mole of a structural unit (2) derived from ethylenically unsaturated monomer having a hydroxyl group (the total of the structural unit (1) and the structural unit (2) is 100% by mole).

Cell culture substrate having an acrylate structural unit and a monomer structural unit

Provided is a method for producing an antithrombotic coating material in which a high molecular weight polymer can be obtained by a solution polymerization using a radical polymerization initiator. The above-mentioned task is achieved by a method for producing an antithrombotic coating material, including steps of: preparing a methanol solution containing a monomer represented by formula (1): wherein in formula (1), R, R, and Rare the same as those described in the specification, respectively; adding a radical polymerization initiator having a 10-hour half-life temperature of 60&#xb0; C. or less to the methanol solution to prepare a polymerization reaction liquid; and polymerizing the monomer.

Method for producing antithrombotic coating material

A hydrophilic copolymer that can form a surface lubricious layer exhibiting superior lubricating property and durability (lubrication retaining property), is provided. A hydrophilic copolymer having a good solvent solubility is provided. A hydrophilic copolymer is provided containing: structural units derived from a polymerizable monomer (A) having a sulfobetaine structure; structural units derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (&#x2014;SOH), a sulfuric acid group (&#x2014;OSOH), a sulfurous acid group (&#x2014;OSOH), and groups of salts thereof; and structural units derived from a polymerizable monomer (C) having a photoreactive group.

Hydrophilic copolymer and medical device

An artificial lung is provided that includes a plurality of porous hollow fiber membranes for gas exchange comprising a hydrophobic polymer material, wherein the hollow fiber membranes have inner surfaces forming lumens and outer surfaces, and wherein at least one of the inner surfaces or the outer surfaces is coated with a polymer-containing solution that has a surface tension of 40 to 55 dyn/cm and that contains a solvent and a polymer having a structural unit represented by Formula (I): wherein in Formula (I), Rrepresents a hydrogen atom or a methyl group, Rrepresents an alkylene group having 1 to 4 carbon atoms, and Rrepresents an alkyl group having 1 to 4 carbon atoms.

Artificial lung and method for manufacturing artificial lung

An artificial lung is provided having a plurality of porous hollow fiber membranes for gas exchange, in which the hollow fiber membranes have outer surfaces, inner surfaces forming lumens, and opening portions through which the outer surfaces communicate with the inner surfaces, any one of the outer surfaces and the inner surfaces is coated with a colloidal solution of an antithrombotic material containing a polymer as a main component, and an average particle size of the colloid is at least 1.5 times a diameter of the opening portions of the hollow fiber membranes. An artificial lung is provided that can effectively suppress leakage of blood plasma components after blood circulation (blood plasma leakage).

A medical instrument includes a first tube body and a second tube body joined to the first tube body by being inserted in the lumen of the first tube body. The second tube body is more rigid than the first tube body. The medical instrument includes a coating layer made of a biocompatible material disposed on the inner peripheral surfaces of the first and second tube bodies. The inner peripheral surface of the second tube body is radially inward of the inner peripheral surface of the first tube body to create a level difference portion. The thickness of the part of the coating layer which coats the level difference portion is larger than the thickness of the level difference portion.

Medical instrument

A catheter assembly includes a hollow catheter; a catheter hub fixed onto a base end portion of the catheter, the catheter hub having an internal passage communicating with an inside of the catheter; a needle disposed in the catheter; a needle hub; a valve element including an opening and closing unit configured to be opened and closed; an operation member including a tubular body, the operation member being configured such that an opening portion of the operation member is insertable into the opening and closing unit to cause the base end side and a tip side of the catheter hub to communicate with each other; a communication unit; and a sealing member including a tubular body, the sealing member being disposed at a base end side of the valve element and being configured to allow the passage of air and prohibit the passage of liquid.

Growing community of inventors

Kanagawa, Japan

Takao Anzai