Daiichi Pharmaceutical Co., Ltd.

Takanori Yasukouchi

Masanori Saito

Hideki Kubota

Satoru Miyauchi

Masayuki Ito

Kayoko Motoki

Hitoshi Iimori

Provided is a compound capable of inhibiting production or secretion of &#x3b2; amyloid protein. A compound represented by the following formula (1): (wherein, Rrepresents a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a cyclic hydrocarbon group which may have a substituent or a heterocyclic group which may have a substituent, Rrepresents a hydrogen atom or a Calkyl group, and X represents &#x2014;S&#x2014;, &#x2014;SO&#x2014; or &#x2014;SO&#x2014;); an N-oxide or S-oxide thereof; a salt thereof; or a solvate thereof; and a medicament containing any of them.

Heterocyclic methyl sulfone derivative

Provided are novel compounds having an inhibitory activity against production or secretion of &#x3b2;-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

&#x3b2;-amyloid protein production/secretion inhibitor

Growing community of inventors

Tokyo, Japan

Takanori Yasukouchi