Juridical Foundation the Chemo-Sero-Therapeutic Research Institute

The Chemo-Sero-Therapeutic Research Institute

Riken Corporation

Adeka Corporation

Tokyo Medical and Dental University

Sapporo Medical University

Takanori Uchida

Noriko Shinya

Hiroshi Kaetsu

Nobuto Fukunaga

Akio Kishida

Tetsuya Higami

Takahiro Sakamoto

Yoshiaki Suzuki

Chikateru Nozaki

Takayuki Imamura

Tsuyoshi Kimura

Ken-ichiro Hiwatari

Masaya Iwaki

Hiroshi Ujiie

Seiichi Funamoto

Jun Negishi

Haruki Obara

Yoshimitsu Ishihara

Hideki Saga

Katsumi Kawakami

Shoko Tokorozaki

Ken-Ichiro Hiwatari

An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

Anti-adhesion material and substitute biomembrane using decellularized tissue

An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.

Artificial blood vessel using decellularized blood vessel sheet

It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material for treating aneurysms, which is composed of a polymer material containing carbon as a constitutional element, and which is produced by modifying at least a portion of the surface thereof by ion bombardment.

Material for aneurysm curing

A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.

Bioabsorbable synthetic nonwoven fabric holding thrombin

An adhesive for tissue capable of uniformly forming a high concentration of fibrin so as to provide a high closing effect is disclosed. The adhesive for tissue comprises a fibrinogen solution and a thrombin solution which solutions are separated from each other. The adhesive is to be mixed and spray coated together with a sterile gas and has a volume ratio of the fibrinogen solution to the thrombin solution of about 2:1 to 10:1. This adhesive is to be sprayed together with a sterile gas for the adhesion or closing of living tissue of a human being or animal.

Tissue adhesive suitable for spray application

Applicator for applying a biocompatible adhesive

Growing community of inventors

Kumamoto, Japan

Takanori Uchida