Nissan Chemical Industries Limited

Jfe Steel Corporation

Daicel Chemical Industries, Ltd.

Chugai Seiyaku Kabushiki Kaisha

Taisho Pharmaceutical Co., Ltd.

Takenaka Corporation

Jfe Metal Products Corporation

Takanori Shimizu

Hiroo Matsumoto

Yoshiaki Watanabe

Takashi Horiuchi

Takaaki Ishii

Kenji Yamazaki

Toshio Nakamura

Taketoshi Okubo

Toshihito Kumagai

Shojiro Kadono

Haruhiko Sato

Kazuhiko Ohrai

Yoshinori Sekiguchi

Takuya Shiraishi

Masahiro Sakaitani

Yoshiyuki Suzuki

Keishi Hayashi

Masateru Ohta

Yasutaka Takada

Nobuya Ishii

Masami Hasegawa

Masataka Minami

Tomohiro Kinoshita

Seishi Watanabe

Koji Toyama

Michiaki Adachi

Kumi Abe

Xiang-Min Sun

Yuri Amada

Shigetada Sasako

Shiro Kawahara

Tomoko Ishizaka

Takayuki Nagatsuka

Osamu Yamada

Yuuichirou Okuno

Takahiro Machinaga

Masakazu Sugiyama

Naohiro Fujita

Takayuki Hirayama

Hiroto Takatsu

Yukio Murakami

Kazuto Nakahira

Hiroori Yasuoka

Hirokazu Nozawa

A binding beam includes a steel form having a bottom plate portion and a pair of side plate portions extending upward from both ends of the bottom plate portion and binding beam concrete placed in a groove portion configured by the bottom plate portion and the pair of side plate portions of the steel form.

Steel-framed concrete beam and method for constructing steel-framed concrete beam

Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MCreceptor antagonistic effect.

Aminopyrrolidine compound

The present invention provides novel &#x3b1;-amino acid derivatives of formula (1): (wherein, R, R, R, R, X and Y are as defined in the claims) or pharmaceutically acceptable salts, prodrugs or solvates thereof. The derivatives of formula (1) have &#x3b2;ARK1 inhibitory activity and are useful for preventing or treating heart failure. Moreover, the derivatives of formula (1) also have antitumor activity, particularly dual inhibitory activity on Aurora kinase and CDK, and are useful for cell proliferative diseases such as cancer.

&#x3b1;-amino acid derivatives and medicaments containing the same as an active ingredient

There is provided a method for producing aminobenzopyran compound, which results in little wastes, has no influence on reactors and necessitates a simple work-up procedure. Concretely, it is a method for producing aminobenzopyran compound of formula (2) characterized by reducing a nitro group on 2,2-dimethyl 2H-1-benzopyran compound of formula (1) with hydrazine in the presence of a metal catalyst.

Process for producing aminobenzopyran compound

A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde important as intermediate for the synthesis of pharmaceuticals, efficiently from an unnecessary antipode, is provided. A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde represented by the formula (III): which comprises treating a compound represented by the formula (I) or (II): (wherein A is &#x2014;CHOH or &#x2014;C(O)&#x2014;, and R is a hydrogen atom, a Calkyl group which may be branched, a phenyl group, an alkali metal ion or an alkaline earth metal ion) with ozone, followed by reduction with an inorganic sulfur compound or by hydrogenation for reduction decomposition.

Process for preparation of a quinolinecarbaldehyde

There is provided a process for producing an acetylene compound useful as an intermediate of pharmaceuticals, from 4-nitrofluorobenzene, in industrially and economically advantageous manner. Concretely, it is a method for producing an acetylene compound of formula (3)characterized by reacting 4-nitrofluorobenzene of formula (1)with an alkoxide of 2-methyl-3-butyn-2-ol of formula (2)at &#x2212;20 to 10&#xb0; C.

Process for producing acetylene compound

A process for producing a benzylamine compound represented by formula (2), which comprises reacting a benzaldehyde compound represented by formula (1) with an amino acid in the presence of an acid.

Process for producing benzylamine compound

A process for producing 2-cyclopropyl-4-(4-fluorophenyl)-quinoline-3-carbaldehyde, which entails oxidizing 2-cyclopropyl-4-(4-fluorophenyl)-3-hydroxymethylquinoline with a salt of a hypohalogenous acid in the presence of a quaternary ammonium salt.

Process for producing quinolinecarbaldehyde

Growing community of inventors

Funabashi, Japan

Takanori Shimizu