John Wayne Cancer Institute

Wakunaga Seiyaku Kabushiki Kaisha

Wakunaga Phaemaceutical Co., Ltd.

Wakunga Seiyaku Kabushiki Kaisha

Takanori Oka

Akio Yamane

Reiko F Irie

Kenichi Miyoshi

Hironari Matsunaga

Satoru Nakagami

Takao Tanaka

The present invention provides CD36 mutant gene and methods and kits for diagnosing diseases caused by a lipid metabolism abnormality.

CD36 mutant gene and methods for diagnosing diseases caused by abnormal lipid metabolism and diagnostic kits therefor

A tumor associated protein has been discovered to exhibit immunoreactivity to human monoclonal antibody L92. A ten amino acid peptide segment of the protein and a fourteen amino acid peptide which contains the ten amino acid peptide has also been isolated and exhibits immunoreactivity to the same antibody. Using truncated fusion proteins, the minimum recognition site for antibody binding was determined to be four amino acids. Also disclosed are polypeptide compositions against human tumors that includes the polypeptides or protein of the present disclosure, as well as antibodies reactive with these polypeptides that may be employed directly for treatment or diagnosis. A certain embodiment of the present invention is also the DNA sequence encoding the ten amino acid peptide and the DNA encoding the fourteen amino acid peptide which also exhibits immunoreactivity to human monoclonal antibody L92 and cytotoxic T cells.

Method of treating cancer with a 43 kD human cancer antigen

Methods for enhancing an immune response from a 43 KD human cancer

Method and nucleic acid-concentratiing assay kit for concentrating

Primer for gene amplification, method for nucleic acid discrimination

Immunoreactive peptide sequence from a 43 kD human cancer antigen

Immunoreactive peptide sequence from a 43 KD human cancer antigen

Method of nucleic acid-differentiation and assay kit for nucleic acid

An intended nucleic acid is determined in a sample by a method in which at least one of the nucleic acid strands of the intended nucleic acid is subjected to hybridization with a primer and to chain-extension reaction over the primer to form a synthesized nucleic acid which is complementary to and in hybridization with the strand; a copy of the intended nucleic acid is obtained, which copy is (a) the nucleic acid of the double-stranded double produced by the chain-extension reaction, or (b) the synthesized nucleic acid freed from the double-stranded nucleic acid, or (c) a double stranded nucleic acid form from a pair of the synthesized nucleic acids complementary with each other; and it is determined whether the copy is present in the sample thereby to know whether the intended nucleic acid is in present in the sample.

Method for detecting target nucleic acid in specimen

Growing community of inventors

Hiroshima, Japan

Takanori Oka