Kabushiki Kaisha Yakult Honsha

Niles Parts Company, Ltd.

Microbial Chemistry Research Foundation

Takanori Ogawa

Seigo Sawada

Hideaki Shimizu

Takashi Yaegashi

Hiroyuki Nishiyama

Hiroshi Nagata

Atsuhiro Abe

Miyuki Uchida

Masakatsu Shibasaki

Masao Fukuda

Naoya Kumagai

Tomio Furuta

A catalyst, which is obtained by mixing a compound expressed by the following Structural Formula (1), a nitroalkane compound, a neodymium-containing compound, a sodium-containing compound, and a carbon structure: 

Catalyst and method for producing optically active anti-1,2-nitroalkanol compound

The present invention is to prepare efficiently 2'-amino-5&#x2032;-hydroxypropiophenone corresponding to the AB-ring part of camptothecin (CPT) skeleton and a tricyclic ketone corresponding to the CDE-ring part in order to provide efficiently CPT by the total synthesis, which is a starting material for irinotecan hydrochloride and various kinds of camptothecin derivatives, and to provide stably CPT and its derivatives.

Method of synthesizing camptothecin-relating compounds

Process for producing camptothecin

The present invention relates to new camptothecin derivatives shown by the below formula, which are water-soluble and excellent in an anti-tumor activity, and to salts thereof.

Camptothecin derivatives

The present invention relates to taxane derivatives each represented by the following formula (1):

Taxane derivatives

An electromagnetic relay in which an iron core 2 is fixed to a yoke 3, and one end of the yoke 3 is fixed by press-fitting to a base 4. The base 4 is formed with a yoke-receiving groove 4b into which tongue pieces 3e, 3e at one end of the yoke 3 are press-fitted, and a cutout groove 4c into which a head portion 2c of the iron core 2 is received. The yoke 3 is formed with a seal projection 3f disposed by insertion in an opening end of a cutout groove 4c of the base 4. This construction of the electromagnetic relay eliminates poor operation by preventing metal chips produced during assembly from adhering to electrical contacts of the relay.

Structure of electromagnetic relay

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Tokyo, Japan

Takanori Ogawa