Mitsubishi Electric Corporation

Astellas Pharma Gmbh

Takanori Koike

Osamu Morimoto

Hiroyuki Okano

Yoji Onaka

Kosuke Miyawaki

Takashi Matsumoto

Jun Maeda

Kenji Negoro

Kosuke Tanaka

Hiroaki Tanaka

Kazuhiro Yokoyama

Itsuro Shimada

Hajime Takamatsu

Taisuke Takahashi

Takeshi Hatomura

Hiroki Maruyama

Naomichi Tamura

Susumu Yamaki

Tomoaki Abe

Kazushi Watanabe

Takahiro Nigawara

Kazuyuki Kuramoto

Shigeki Kunikawa

Tomoyoshi Imaizumi

Michinori Akaiwa

Keisuke Arakawa

Takanobu Araki

Yoshiki Satake

Masashi Shimazaki

Masaaki Hirano

Hiroyuki Morimoto

Shinsaku Kusube

Seiji Yoshimura

Koji Azuma

Shigeo Takata

Noriyuki Kawano

Hirofumi Yamamoto

Takahiko Kobayashi

Hideyuki Watanabe

Yusuke Inagaki

Kazuyoshi Shinozaki

Eiji Kawaminami

Issei Tsukamoto

Hiroyuki Hisamichi

Shunichiro Matsumoto

Shuhei Mizutani

Isao Kinoyama

Yoshihiro Taniguchi

Nobuyuki Shiraishi

Kei Ohnuki

Ryosuke Munakata

Tatsuhisa Takahashi

Kayoko Mihara

Hiroaki Hoshii

Takashi Shin

Daisuke Sasuga

Toshiyuki Kusayama

Hiroki Fukudome

Tomoaki Kawano

Kazuhiko Osoda

A refrigeration cycle apparatus includes a heat source side unit, a relay unit, and a plurality of load side units, the heat source side unit and the relay unit are connected by using a low-pressure pipe and a high-pressure pipe, and the relay unit and each of the plurality of load side units are connected by using a corresponding liquid branch pipe and a corresponding gas branch pipe. The heat source side unit includes a compressor configured to compress refrigerant, at least one flow switching valve configured to change a passage of refrigerant based on an operation mode, and at least one heat source side heat exchanger, and the relay unit includes six-way valves or pairs of four-way valves.

Refrigeration cycle apparatus

A refrigeration cycle apparatus includes: a refrigerant circuit in which a compressor, a heat-source-side heat exchanger, a first expansion device, a second expansion device, and a load-side heat exchanger are sequentially connected by refrigerant pipes and in which refrigerant is circulated; a controller that controls the refrigerant circuit; a bypass pipe extending from a liquid pipe between the first expansion device and the second expansion device toward a suction side of the compressor; a third expansion device provided at the bypass pipe to decompress the refrigerant that flows through the bypass pipe; and a refrigerant cooler provided at the bypass pipe and downstream of the third expansion device to cause heat exchange to be performed between the refrigerant decompressed by the third expansion device and heat generated from the controller.

A refrigeration cycle device according to the present disclosure includes: a refrigerant circuit including a compressor, a heat-source-side heat exchanger, a first expansion device, and a load-side heat exchanger, refrigerant cycling through the compressor, the heat-source-side heat exchanger, the first expansion device, and the load-side heat exchanger; a plurality of controllers configured to control the refrigerant circuit; a bypass pipe branching from a high pressure pipe on a discharge side of the compressor and connected to a low pressure pipe on a suction side of the compressor; a second expansion device provided to the bypass pipe, and configured to adjust a flow rate of the refrigerant flowing through the bypass pipe; and a plurality of refrigerant coolers provided to the bypass pipe, and configured to cool the plurality of controllers by using the refrigerant the flow rate of which is adjusted by the second expansion device, each of the plurality of refrigerant coolers including a refrigerant cooling pipe and a plate, the refrigerant cooling pipe forming the bypass pipe, the plate being joined between the refrigerant cooling pipe and a controller of the plurality of controllers.

Refrigeration cycle device

A header includes a plurality of branch tubes and a header manifold. If refrigerant flowing into the header manifold forms a pattern of annular flow or churn flow, tips of the branch tubes inserted into the header manifold pass through a liquid-phase portion having a thickness &#x3b4; [m] and reach a gas-phase portion. The thickness &#x3b4; [m] of the liquid-phase portion is defined as &#x3b4;=G&#xd7;(1&#x2212;x)&#xd7;D/(4&#x3c1;&#xd7;U), where G is a flow speed [kg/(ms)] of the refrigerant, x is a quality of the refrigerant, D is an inside diameter [m] of the header manifold, &#x3c1;is a liquid density [kg/m] of the refrigerant, Uis a reference apparent liquid speed [m/s] that is a maximum value within a range of variation in an apparent gas speed of the refrigerant flowing into a flow space of the header manifold. The reference apparent liquid speed U[m/s] is defined as G(1&#x2212;x)/&#x3c1;.

Air-conditioning apparatus and method of using air-conditioning apparatus

The air-conditioning apparatus includes a heat exchanger including a plurality of heat transfer tubes and a header manifold an axial fan and a refrigerant circuit. When the distance from the center of the flow space in the horizontal plane is represented on a scale of 0 to 100%, where 0% represents the center of the flow space and 100% is the position of the wall surface of the header manifold, among the plurality of branch tubes located within a height range that allows the blade to rotate, the majority of the branch tubes located at or below the height of the boss are connected to the header manifold such that their distal ends are positioned at 0 to 50% of the distance from the center, and the majority of the branch tubes located above the height of the boss are connected to the header manifold such that their distal ends are positioned at more than 50% of the distance from the center.

Air-conditioning apparatus

A heat sink includes a pipe through which cooled fluid flows and a cooling block having a first face on which the pipe is placed and a second face to which a heat emitting element is attached. The cooling block has a contact region and a noncontact region at positions where the cooling block faces the pipe. In the contact region, the first face contacts the pipe. In the noncontact region, the first face faces the pipe with a gap therebetween. The contact region is included in a projection region defined by projecting a region of attachment of the heat emitting element onto the first face.

Heat sink

[Problem] To provide a compound which is useful as an active ingredient for a pharmaceutical composition for preventing or treating urine storage dysfunction, voiding dysfunction, lower urinary tract dysfunction, and the like. [Means for Solution] The present inventors have found that a thiazole derivative substituted with pyrazinylcarbonylamino at the 2-position is an excellent muscarinic Mreceptor-positive allosteric modulator and is expected as an agent for preventing or treating bladder/urinary tract diseases associated with bladder contractions via a muscarinic Mreceptor, thereby completing the present invention. 2-Acylaminothiazole derivative or a salt thereof of the present invention is expected as an agent for preventing or treating bladder/urinary tract diseases associated with bladder contractions via a muscarinic Mreceptor, for example voiding dysfunction such as underactive bladder.

2-acylaminothiazole derivative or salt thereof

A refrigerant distributor branches refrigerant flowing in a refrigerant circuit into three, and includes a first bifurcate flow divider including a first pipe portion forming one inflow port, a second pipe portion and a third pipe portion forming two outflow ports communicating with the inflow port of the first pipe portion, and a second bifurcate flow divider including a fourth pipe portion forming one inflow port, and a fifth pipe portion and a sixth pipe portion forming two outflow ports communicating with the inflow port of the fourth pipe portion. The outflow port of the third pipe portion and the inflow port of the fourth pipe portion communicate with each other, and an angle &#x3b8; formed by a first plane passing through the first bifurcate flow divider and a second plane passing through the second bifurcate flow divider is between 60 and 120 degrees.

Refrigerant distributor and air-conditioning apparatus

A refrigeration cycle apparatus includes a refrigerant circuit, through which refrigerant is circulated, including a compressor, a heat source side heat exchanger, a first expansion device, and a load side heat exchanger, a controller controlling the refrigerant circuit, and a bypass pipe that branches off from a high-pressure pipe extending from the compressor to the first expansion device and that is connected to a low-pressure pipe on a suction side of the compressor. The apparatus further includes a precooling heat exchanger that is provided in the bypass pipe and that cools the refrigerant diverted to the bypass pipe, a second expansion device that is provided in the bypass pipe and that reduces a pressure of the refrigerant cooled by the precooling heat exchanger, and a refrigerant cooler that is provided in the bypass pipe and that cools the controller with the refrigerant reduced in pressure by the second expansion device.

A heat exchanger includes first and second headers connected to end portions of heat transfer tubes. The second header includes a header pipe defining a flow space that communicates with the heat transfer tubes and, when the heat exchanger acts as an evaporator, allows refrigerant in a two-phase gas-liquid state to pass through the flow space into the heat transfer tubes. A bypass pipe is disposed between an entrance portion and the first header. The entrance portion has an entrance distance L between a connection end portion connected to a refrigerant pipe and a central axis of the bypass pipe. The entrance distance L of the entrance portion satisfies L&#x2265;5di, where di is an inner diameter of a flow space of the header pipe on an orthogonal plane orthogonal to a direction of refrigerant flow. The bypass pipe is inserted in the flow space of the entrance portion.

Heat exchanger and air-conditioning apparatus

A refrigeration cycle apparatus includes a refrigerant circuit, a controller, a bypass pipe, a refrigerant cooler, a second expansion device, and a controller temperature sensor. In a case where a temperature measured by the controller temperature sensor is lower than or equal to a set temperature in a state where an opening degree of the second expansion device is controlled to an instruction opening degree that is lower than or equal to a set opening degree, the controller is configured to perform foreign substance release control where the controller is configured to increase the opening degree of the second expansion device and then is configured to return the opening degree of the second expansion device to the instruction opening degree.

Refrigeration cycle apparatus having foreign substance release control

A refrigeration cycle apparatus includes a main circuit through which refrigerant circulates and in which a compressor, a condenser, a first expansion device, a centrifugal gas-liquid separator that separates refrigerant into gas refrigerant and liquid refrigerant by using centrifugal force, and an evaporator are connected by refrigerant pipes; and a bypass that returns the gas refrigerant obtained through the separation by the gas-liquid separator to a suction side of the compressor. The gas-liquid separator includes a cylindrical container, an inflow pipe, a gas outflow pipe, and a liquid outflow pipe. The main circuit includes a second expansion device provided between the liquid outflow pipe of the gas-liquid separator and the evaporator. The gas refrigerant discharged from the gas outflow pipe of the gas-liquid separator flows into the bypass, and the bypass is provided with a third expansion device.

Gas-liquid separator system for refrigeration cycle apparatus

A refrigeration cycle apparatus includes a refrigerant circuit through which refrigerant circulates, a control box in which equipment for controlling the refrigeration cycle apparatus is accommodated, and a refrigerator for cooling a heat emitting body exposed from an opening of the control box. The heat emitting body is the equipment accommodated in the control box. The refrigerator includes a cooling body in contact with the heat emitting body, and a refrigerant pipe through which the refrigerant circulating through the refrigerant circuit passes to cool the cooling body. The refrigerant pipe is in contact with the cooling body. The pipe contact surface is different from the heating-body contact surface. The cooling body has a recessed portion at which the cooling body and the heat emitting body are not in contact with each other. The recessed portion is formed in the heating-body contact surface and spaced from the control box.

[Problem] Provided is a compound which is useful as an active ingredient of a pharmaceutical composition for treating lung cancer. [Means for Solution] The present inventors have studied a compound useful as an active ingredient of a pharmaceutical composition for treating lung cancer, and as a result, it was found that a quinazoline compound has an excellent G12C mutation KRAS inhibitory activity, and which can be used as a therapeutic agent for lung cancer, and thereby the present invention has been completed. The quinazoline compound of the present invention and a salt thereof may be used as the therapeutic agent for lung cancer.

Quinazoline compound

Growing community of inventors

Tokyo, Japan

Takanori Koike