Pharmadesign, Inc.

Kabushiki Kaisha Yakult Honsha

Shizuoka Prefecture

Kumamoto Health Science University

Pharma IP General Incorporated Association

General Incorporated Association Pharma Valley Project Supporting Organization

Takane Yokotagawa

Osamu Takahashi

Akira Asai

Naohisa Ogo

Toshio Furuya

Yasuto Akiyama

Kenji Matsuno

Tadashi Ashizawa

Tadashi Okawara

Masahiro Sokabe

The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR; and Rto Rand Reach represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof. 

STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient

It is intended to provide novel polypeptides which specifically inhibit the activity of a mechano-sensitive channel; and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing these polypeptides or salts thereof. The above objects can be achieved by using polypeptides having amino acid sequences represented by SEQ ID NO:1 (TVP003), SEQ ID NO:2 (TVP004) and SEQ ID NO:3 (TVP005), salts of these polypeptides, and mechano-sensitive channel inhibitors or remedies for atrial fibrillation containing the same.

Low-molecular weight peptides inhibiting ion channel activity

Growing community of inventors

Tokyo, Japan

Takane Yokotagawa