Nippon Kayaku Kabushiki Kaisha

Oncolys Biopharma, Inc.

Toshiyuki Sakai

Takamichi Sato

Seiichi Saito

Takashi Harada

Makoto Morita

Hideji Fujii

Masashi Nagai

Tsugio Tomiyoshi

Tomio Morino

Takaaki Nishikiori

Arihiro Tomura

Kan Saiga

Yasutada Imamura

Shigehide Kagaya

Yoshikazu Sukenaga

Kazuhiro Tokunaka

Hidemitsu Sugihara

Atsushi Kuwahara

A monoclonal antibody, wherein the monoclonal antibody specifically binds to a single-chain type IV collagen polypeptide, and wherein the monoclonal antibody is obtained by a hybridoma line of Anti NK-Antigen monoclonal antibody #141 having Accession No: FERM BP-11300.

Anti-single-chain type IV collagen polypeptide antibody, pharmaceutical drug, diagnostic, preventive, or therapeutic drug for tumour containing the antibody

In accordance with the present invention, there are provided a gene encoding the promoter region of a protein p51 which is capable of inducing cell death, and a gene encoding the 5'-untranslated region of p51. These genes are useful in diagnosing and treating diseases including cancer caused by abnormal regulation of cell propagation. Furthermore, in accordance with the present invention, there are provided the antisense DNAs and the antisense RNAs of these genes, nucleic acid probes comprising parts or all of these genes, methods of detecting the above genes of the present invention or analogous genes using the nucleic acid probes, transformants in which the above gene of the present invention has been introduced, and methods of screening drugs using them. These genes are also useful in diagnosing and treating diseases including cancer, etc.

Gene encoding promoter domain of tumor suppressor gene P51 and use thereof

A novel cystacycline derivative which has an excellent effect of promoting the differentiation of neurons and is useful as a remedy for central nervous system disorders, a remedy for peripheral nerve disorders, etc.

Compound having effect of promoting neuron differentiation

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Yono, Japan

Takamichi Sato