Teijin Limited

Juridical Foundation the Chemo-sero-therapeutic Research Institute

Osaka Bioscience Institute

Takami Arai

Jun Suzuki

Yorimasa Suwa

Noboru Yoshioka

Katsutoshi Sakurai

Satoshi Sugiura

Yataro Ichikawa

Masaaki Suzuki

Yasuyoshi Watanabe

Hiroshi Mizokami

Seiichi Yokoyama

Michiyuki Tokashiki

Takaharu Tsutsumi

Kenji Ishimaru

Akira Tanokura

Yoshinobu Miyatsu

Yoshiharu Takazawa

Kimihiko Hamamoto

Yumiko Watanabe

Kenji Nagura

Masamichi Motoki

Takumi Satoh

Yosuke Kataoka

A compound represented by the Formula below, and an agent for the remedy of neural damage having the said compound as the active ingredient. [Here, G represents G1 shown below Rrepresents, hydrogen atoms and acyl groups, W represents single bonds and alkylenes, m represents 0 or 1, Rand Rrepresent hydrogen atoms, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, aromatic hydrocarbon groups and heterocyclic groups, and Rrepresents hydrogen atoms, acyl groups and alkoxycarbonyl groups. Arepresents, single bonds, &#x2014;O&#x2014;, &#x2014;NR&#x2014;, and &#x2014;S(&#x2550;O)&#x2014;, Aand Arepresent single bonds, aliphatic hydrocarbon groups, alicyclic hydrocarbon groups, heterocyclic groups and phenylene groups, and Arepresents single bonds, carbonyl groups and aliphatic hydrocarbon groups. Rand Rrepresent hydrogen atoms, alkyl groups, cycloalkyl groups, phenyl groups and heterocyclic groups. The previously mentioned functional groups may be substituted.]

Neuropathy improvers containing nitrogenous compounds as the active ingredient

The present invention provides a neurodegenerative disease therapeutic agent containing as its active ingredient a (15R)-isocarbacycline derivative indicated by the following formula [I] or a 15-deoxy-isocarbacycline derivative indicated by the following formula [III]:(wherein, Rrepresents a C-Calkylene group, and Rrepresents a hydrogen atom, a C-C, alkyl group or protective group); or,(wherein, Rand Rare the same as those defined in formula [I]).

Neuropathy remedies

Medium for culturing animal cells

An apparatus for cell culture by perfusion comprising a cell culture tank for suspension culture, said cell culture tank having a suspension cell culture zone, a cell settling zone, an opening for discharging a spent culture medium from the settling zone and an opening for supplying a culture medium to the suspension culture zone, the suspension culture zone and the setting zone being separated by a partition therebetween in a manner to communicate with each other in the lower portion of the settling zone, and the settling zone being formed between the side wall of the cell culture tank and the partition. Another type of apparatus for cell culture having a unit in which main culturing and settling are carried out in a cell settling zone, and a multiunit cell culture apparatus having at least two culturing units which are stacked longitudinally are also described. A method for culturing cells by perfusion in the culture apparatus which comprises withdrawing a substantially cell-free culture medium from the settling zone and introducing a fresh culture medium into the suspension culture zone.

Culture apparatus and method

Growing community of inventors

Hino, Japan

Takami Arai