Eli Lilly and Company

Takako Wilson

Daniel Jon Sall

Philip Arthur Hipskind

Jolie Anne Bastian

Karen Lynn Lobb

William Thomas McMillen

Jose Eduardo Lopez

Ling Liu

Jeffrey Daniel Cohen

Joshua Ryan Clayton

Ryan Edward Stites

Bharvin Kumar Patel

Jacqueline Mary Wurst

Adel Ahmed Rashad Ahmed

Renhua Li

Yiqing Feng

Aaron David Wrobleski

Julia Marie Clay

Michelle Lee Thompson

The present invention provides a compound of Formula I:

Glucocorticoid receptor agonists

The present invention provides a compound of Formula I: wherein R is H or Ris H, halogen, C1-C3 alkyl, C3-C6 cycloalkyl, C1-C3 alkoxy, C2-C3 alkenyl, OCF, Ris H, halogen, C1-C3 alkyl, C1-C3 alkoxy, or C2-C4 alkenyl;Ris NH, or CHNH; andX is O, OCH, OCHCH, OCH(CH), CHO, SCH, CHS, CH, NHCH, CHNH, N(CH)CH, CHCH, C&#x2261;C, or a bond, wherein X is connected to phenyl ring A at the ortho or the meta position, or a pharmaceutically acceptable salt thereof, wherein the compound of Formula I, or pharmaceutically acceptable salt thereof is useful for treating autoimmune and inflammatory diseases, such as atopic dermatitis and rheumatoid arthritis.

Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs.

MET antibody drug conjugates

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Indianapolis, IN, United States of America

Takako Wilson