Toyama Chemical Co., Ltd.

Takako Hori

Isamu Saikawa

Hisatsugu Tsuda

Shohachi Murakami

Chosaku Yoshida

Ryuko Takeno

Joji Nakano

Yasuo Kiba

Jun Nitta

Sumiko Kishimoto

Hiroshi Sakai

Takashi Yasuda

Toyoo Maeda

Hisashi Minami

Kenzo Tamai

Masatoshi Sugita

Yoshiko Yamamoto

Shinji Miyabara

Isao Myokan

Takashi Nagai

Hidetada Mikami

Nobuhisa Taya

Masaaki Shibata

Kenji Ohta

Keishi Funaki

Isao Myoukan

A novel isoindole derivative represented by general formula [1] or a salt thereof: ##STR1## which has an excellent antitumor activity and low toxicity.

Isoindole derivatives and salts thereof and antitumor agent comprising

Novel substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases lower warm-blooded animals. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.

Novel substances having carcinostatic and immunostimulating activity,

This invention relates to a novel 5-fluoro-2'-deoxyuridine derivative and a salt thereof which have an antitumor effect on mammals, a process for producing the same, and an antitumor agent containing the same.

Novel 5-fluoro-2'-deoxyuridine derivatives and salts thereof, process

Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for

Novel TF-2 substances having antitumor and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human beings. This disclosure concerns such substances and a process for preparing the same and an antitumor agent containing the same.

Novel substances having antitumor and immunostimulating activity,

This invention relates to a process for producing a TF-500 substance having carcinostatic and immunostimulating activities, which comprises subjecting organisms belonging to the Fusobacterium genus to extraction treatment with a dialkyl sulfoxide and obtaining said TF-500 substance from the resulting extract.

Process for preparing substance having carcinostatic and

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition salts

Novel 1-(4-piperidiniobenzyl)-2,3-dioxopiperazine derivatives or acid

Novel TF-2 substances having carcinostatic and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human being. This disclosure concerns such substances and a process for preparing the same and a carcinostatic agent containing the same.

Substances having carcinostatic and immunostimulating activity

A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and a salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives and salts thereof

4-[4-(Thiazolyl-amino)benzyl]-2,3-dioxopiperazine derivatives, acid

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Toyama, Japan

Takako Hori