Mitsui Chemicals, Inc.

Mitsui Toatsu Chemicals, Incorporated

Takaichi Miwa

Takahisa Oguchi

Hajime Iizuka

Kazutoshi Horikomi

Kazuya Sakai

Norio Ohto

Hiroshi Nagase

Naruyoshi Mita

Takeshi Kamioka

Yoji Aoki

Shoji Kawashima

Shinji Takahashi

Since a compound represented by general formula (1), its pharmaceutically acceptable salt and a hydrate of the pharmaceutically acceptable salt have high antipsychotic activity, they may be used as an active ingredient for preparation of an antipsychotic. ##STR1## Also provided are an optical resolution method of the above compound and an intermediate for preparation of the compound.

Pyrrolidinone derivatives

Antipsychotics and ischemic cerebral disease therapeutics comprising as an effective ingredient a compound represented by the following formula (1) or (2): ##STR1## or a salt thereof. These drugs do not induce extrapyramidal side effects.

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Chiba-ken, Japan

Takaichi Miwa