Otsuka Pharmaceutical Company, Limited

Takahito Yamauchi

Kenji Otsubo

Yuji Ochi

Tomoichi Shinohara

Takeshi Kuroda

Kunio Oshima

Takumi Sumida

Takahiro Tomoyasu

Tae Fukushima

Kazuhide Ohta

Hironobu Ishiyama

Hitoshi Nagao

Chiharu Kitajima

Masaaki Takano

Michiaki Tominaga

Kaoru Abe

Kenji Nakaya

Fujio Tabusa

Isao Takemura

Toyoki Mori

Yoshihisa Tanada

Kazuyoshi Nagami

The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein:

Quinolone compound and pharmaceutical composition

The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; Rand Reach represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; Ris a hydrogen atom, etc; Ris a hydrogen atom, etc; and Ris a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

Carbostyril compound

Thiazole derivative

Growing community of inventors

Osaka, Japan

Takahito Yamauchi