Eisai R&d Management Co., Ltd.

Takahisa Sakaguchi

Tomohiro Matsushima

Atsushi Kamada

Shuji Shirotori

Kazunori Wakasugi

Shinya Abe

Mitsuo Nagai

Akihiko Tsuruoka

Keiko Takahashi

Kazumasa Nara

Kazuhiro Yoshizawa

Taiju Nakamura

Yusuke Ayata

Yosuke Ueki

Itaru Arimoto

Masaharu Gotoda

Nobuo Yoshida

Kentaro Nagane

Hirokazu Kito

Anjali Joshi

Shusuke Sano

Naoko Suzuki

Yung Yueh Hsu

Pierre Souillac

Takahiro Ozawa

Kazuhiro c/o Eisai Co Ltd Yoshizawa

Itaru c/o Eisai Co Ltd Arimoto

Yusuke c/o Eisai Co Ltd Ayata

The present invention provides a method for suppressing bitterness of a quinoline derivative.

Method for suppressing bitterness of quinoline derivative

Provided is a container including a main body, a lid body, and a fixing mechanism that fixes the lid body to prevent the lid body from opening from the main body when the lid body is closed, the fixing being released when the lid body moves to a front side with respect to the main body. Cutouts are formed in side plates of the main body. The container is configured such that, by a rear plate tilting forward toward the cutouts of the side plates, the lid body moves to the front side with respect to the main body and the fixing of the lid body is released, and as the rear plate and a top plate of the lid body form a single plane, the top plate rises and the lid body opens.

Container

The invention provides acid addition salts of the compounds represented by formula (1) or (2), or crystals thereof, and processes for preparing the same. The salts or crystals have HGFR inhibitory activity and excellent physical properties (solubility, safety, etc.) and are therefore useful as anti-tumor agents, angiogenesis inhibitors and inhibitors for metastasis for a various types of tumor. 

Phenoxypyridine derivative salts and crystals thereof, and process for preparing the same

A process for preparing a compound represented by the formula (I): comprising reacting a compound represented by the formula (II) or salt thereof: with a compound represented by the formula (III): in the presence of a condensation reagent,wherein Rrepresents 1) optionally substituted azetidin-1-yl, 2) optionally substituted pyrrolidin-1-yl, 3) optionally substituted piperidin-1-yl, etc.; R, R, Rand Rmay be the same or different and each represents hydrogen or fluorine; and Rrepresents hydrogen or fluorine.

Process for preparing phenoxypyridine derivatives

A crystal of a 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide hydrochloride, hydrobromide, p-toluenesulfonate, sulfate, methanesulfonate or ethanesulfonate, or a solvate thereof.

Crystalline form of the salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide or the solvate of the salt and a process for preparing the same

An amorphous form of a salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.

Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same

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Tsukuba, Japan

Takahisa Sakaguchi