Aska Pharmaceutical Co., Ltd.

Teikoku Hormone Mfg. Co., Ltd.

Other

Teikoju Hormone Mfg. Co., Ltd.

Takahisa Saito

Shuichiro Sato

Jun Sato

Koichi Hasumi

Shuji Ohta

Hajime Asano

Katsuyuki Keino

Michitaka Sato

Nobuyoshi Minami

Satoshi Doi

Akira Asagarasu

Norio Yamamoto

Teruaki Matsui

Motohiro Kobayashi

Arihiro Kanada

Hiroyuki Suzuki

Kenji Shimizu

Kazuhiro Sasaki

Koichi Minato

Yasuhiro Matsumoto

Kazuhiko Shirota

Mami Okada

Jun-ya Kato

Hiroya Yajima

Tomoya Fujisawa

Jun-Ya Kato

Akiko Sugimoto

Hiroshi Azuma

Shuji Ota

Haruo Yamashita

Katsura Suzuki

Hidehisa Hamasaki

A powder preparation for nasal administration containing a particulate of steroid hormones having an average particle size of 50 to 300 &#x3bc;m as an active ingredient is prepared.

Powder preparation for nasal administration

This invention offers isoxazole derivatives represented by the following formula (I) 

Pyridylisoxazole derivatives

The invention discloses isoxazole derivatives represented by a formula, 

Pyrimidinylisoxazole derivatives

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein Ris &#x2014;CH(OH)&#x2014;CH(R)-(A)-Y, &#x2014;CH&#x2014;CH(R)-(A)-Y, &#x2014;CO-B-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; Ris a hydrogen atom or a lower alkyl group; Bis &#x2014;CH(R)&#x2014; or &#x2014;N(R)&#x2014;; and n is 0 or 1); Ris a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; Ris a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &#x3b1;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases 

Substituted pyrazole compounds

Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R is &mdash;CH(OH)&mdash;CH(R )&mdash;(A) &mdash;Y, &mdash;CH &mdash;CH(R )&mdash;(A) &mdash;Y, &mdash;CO&mdash;B &mdash;A&mdash;Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R is a hydrogen atom or a lower alkyl group; B is &mdash;CH(R )&mdash; or &mdash;N(R )&mdash;; and n is 0 or 1); R is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.

Aminopyrazole derivatives

4,5-Dihydro-&lsqb;1H&rsqb;-benz&lsqb;g&rsqb;indazole-3-carboxylic acid derivatives represented by the following formula, or their salts, have excellent antagonism to endothelin receptors and are useful as preventives or remedies for diseases such as hypertension, angina pectoris, myocardial infarction, brain infarction, cerebrovascular contraction, renal insufficiency, hepatic dysfunction, arteriosclerosis and post-PTCA restenosis.

4,5-dihydro-&lsqb;1H&rsqb;-benz&lsqb;g&rsqb;indazole-3-carboxylic acid derivatives

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Kawasaki, Japan

Takahisa Saito