Japan Tobacco Inc.

Takahisa Motomura

Hisashi Shinkai

Motohide Satoh

Koichi Suzawa

Hirotsugu Ito

Hiroshi Kawakami

Wataru Watanabe

Hironobu Nagamori

Yuji Matsuzaki

Shuichi Wamaki

Hisateru Aramaki

Satoru Kobayashi

Toru Morita

Yoshiharu Itoh

Takashi Matsuda

Hiroshi Yamamoto

Takuya Matsuo

Takashi Inaba

Takahiro Yamasaki

Koji Ando

Masafumi Inoue

Koji Matsuda

Shuji Miyake

Takao Ito

Tsubasa Takeichi

Hideto Uehara

Kentaro Kondo

Gakujun Shomi

Yasuyuki Kajimoto

Yukishige Ikemoto

A production method of a compound represented by the formula [I]: or a pharmaceutically acceptable salt thereof, or a hydrate thereof.

Production method for pyrazole-amide compound

A compound represented by the following formula:  or a pharmaceutically acceptable salt thereof,and a pharmaceutical use thereof.

Pyrazole-amide compounds and pharmaceutical use thereof

The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.

Fluorene compound and pharmaceutical use thereof

An anti-HIV agent containing, as an active ingredient, a 4-oxoquinoline compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof. The compound of the present invention has HIV integrase inhibitory action and is useful as an anti-HIV agent for the prophylaxis or therapy of AIDS. Moreover, by a combined use with other anti-HIV agents such as protease inhibitors, reverse transcriptase inhibitors and the like, the compound can become a more effective anti-HIV agent. Since the compound has high inhibitory activity specific for integrases, it can provide a safe pharmaceutical agent with a fewer side effects for human.

4-oxoquinoline compound and use thereof as HIV integrase inhibitor

Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2&#x3b8;(&#xb0;) as measured by X-ray powder diffractmetry.

Stable crystal of 4-oxoquinoline compound

4-oxoquinoline compound and use thereof as pharmaceutical agent

Growing community of inventors

Takatsuki, Japan

Takahisa Motomura