Kaneka Corporation

Nippon Steel & Sumitomo Metal Corporation

H. Lundbeck A/s

Takahisa Kato

Yasuyoshi Ueda

Shiro Kitamura

Kazuyoshi Yajima

Akihisa Kanda

Kazuhiro Shimoda

Tomio Yamakawa

Yasuyoshi Hidaka

Keishi Matsumoto

Shuichi Akiyama

Hans Petersen

Yuji Inoue

Robert Dancer

Takashi Yoshida

Toshihiro Takeda

Haleh Ahmadian

Lars Ole Lyngso

Shogo Yamamoto

Koji Muramatsu

Junichi Nishimori

Naoki Taoka

A process for producing on an industrial scale the oxidized coenzyme Q, includes culturing a reduced coenzyme Q-producing microorganism selected from the group consisting of the genus, the genus, the genusand the genus, to obtain microbial cells containing reduced coenzyme Qat a ratio of not less than 70 mole % among the entire coenzymes Q; and one of: (a) oxidizing thus-obtained reduced coenzyme Qto oxidized coenzyme Qand then extracting the oxidized coenzyme Qby an organic solvent; or (b) extracting reduced coenzyme Qby an organic solvent and oxidizing the extracted reduced coenzyme Qto oxidized coenzyme Q.

Process for producing coenzyme Q10

The present invention relates to a process for producing reduced coenzyme Qwhich comprises obtaining microbial cells containing reduced coenzyme Qat a ratio of not less than 70 mole % among the entire coenzymes Q, optionally disrupting the cells and recovering thus produced reduced coenzyme Q. The present invention also relates to a process for producing oxidized coenzyme Qwhich comprises either recovering oxidized coenzyme Qafter oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Qfrom the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Qthereafter. According to the processes of the present invention, reduced coenzyme Qand oxidized coenzyme Qcan be produced simply on the industrial scale.

[object Object]

There is provided an antioxidant agent capable of preventing scale from being produced on the surface of a heated metallic starting material more effectively than the conventional antioxidant agent. The antioxidant agent according to the present invention contains a plurality of glass frits having different softening points and an inorganic compound having a melting point not higher than 600&#xb0; C. The inorganic compound mainly softens in the low-temperature range of about 600&#xb0; C. The plurality of glass frits mainly soften in the low-temperature range of about 600 to 1300&#xb0; C. Therefore, the antioxidant agent covers the surface of metallic starting material in a broad temperature range, oxidizes the surface of metallic starting material, and prevents the production of scale.

Antioxidant agent and process for producing metallic material

There is provided an antioxidant agent excellent in anti-dripping property and anti-peeling property. The antioxidant agent in accordance with the present invention contains a plurality of glass frits having different softening points, potter's clay, and bentonite and/or sepiolite. On account of the potter's clay, the antioxidant agent applied to the surface of a metallic starting material is less liable to drip down. Further, on account of the bentonite and/or sepiolite, the antioxidant agent is less liable to peel off the surface of the metallic starting material.

The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation. 

Method for the separation of intermediates which may be used for the preparation of escitalopram

The present invention relates to a process for producing reduced coenzyme Qwhich comprises obtaining microbial cells containing reduced coenzyme Qat a ratio of not less than 70 mole % among the entire coenzymes Q, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q. The present invention also relates to a process for producing oxidized coenzyme Qwhich comprises either recovering oxidized coenzyme Qafter oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Qfrom the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Qthereafter. According to the processes of the present invention, reduced coenzyme Qand oxidized coenzyme Qcan be produced simply on the industrial scale.

Processes for producing coenzyme Q10

Growing community of inventors

Hyogo, Japan

Takahisa Kato