Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Takahisa Hanada

Koichi Ito

Koki Kawano

Satoshi Nagato

Kohshi Ueno

Masataka Ueno

Shinji Hatakeyama

Yoshihiko Norimine

Hiroyuki Amino

Terence Smith

Makoto Ogo

Anthony John Groom

Leanne Rivers

Toshiaki Tanaka

Toru Watanabe

Noritaka Kitazawa

Akiharu Kajiwara

Takashi Kosasa

Yoichi Kita

Keiichi Sorimachi

Yuji Kazuta

Yoshio Urawa

Hiroyuki Naka

Hiroyuki Higashiyama

Yukio Ishikawa

Minako Saito

Tatsuto Fukushima

Tetsuyuki Teramoto

Novel indansulfamide derivatives or a pharmaceutically acceptable salt thereof such as N-[(1S)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, N-[(1S)-2,2,4,7-tetrafluoro-2,3-dihydro-1H-inden-1-yl]sulfamide, (+)-N-(2,2,4,6,7-pentafluoro-2,3-dihydro-1H-inden-1-yl)sulfamide, have an action of improving Seizure Severity Index (Score) in mice kindling model. Thus the compounds or the salt thereof are expected as a drug for treating epilepsy.

Indanesulfamide derivatives

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof.  In the formula, Q indicates NH, O or S; and R, R, R, Rand Rare the same as or different from each other and each indicates hydrogen atom, a halogen atom, a Calkyl group or a group represented by the formula &#x2014;X-A (wherein X indicates a single bond, an optionally substituted Calkylene group etc.; and A indicates an optionally substituted Caromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

1,2-dihydropyridine compounds, manufacturing method thereof and use thereof

The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R, R, R, Rand Rare the same as or different from each other and each indicates hydrogen atom, a halogen atom, a Calkyl group or a group represented by the formula &#x2014;X-A (wherein X indicates a single bond, an optionally substituted Calkylene group etc.; and A indicates an optionally substituted Caromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).

1,2-dihydropyridine compounds, process for preparation of the same and use thereof

Heterodiazinone derivatives

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Ibaraki, Japan

Takahisa Hanada