Takeda Chemical Industries, Inc.

Takeda Chemical Company, Ltd.

Takahiro Saraie

Yutaka Kawamatsu

Eiko Imamiya

Yukihiko Hamuro

Yasuhiko Kawano

Toshihiro Ishiguro

Harutoshi Yoshikawa

Kenya Kawashima

Urea derivatives of the general formula: ##STR1## wherein R.sup.1 stands for a lower alkly group; and R.sup.2 stands for a lower alkyl group or a lower alkoxy group, or a salt thereof, are novel and have a strong herbicidal activity against various species of weeds and shows a very low phytotoxicity to crop plants.

Herbicidal pyridyl-ethoxy-phenyl urea derivatives

.alpha.-CHLOROCARBOXYLIC ACIDS OF THE FORMULA ##STR1## wherein Y stands for a lower alkyl group having 1 to 6 carbon atoms or a phenyl group, a benzoyl group or a phenylalkyl group having 7 to 11 carbon atoms, which may have a lower alkyl group having 1 to 3 carbon atoms, a lower alkoxy group having 1 to 3 carbon atoms or a halogen on the phenyl rings as a substituent; R.sup.1 stands for a lower alkylene group having 1 to 4 carbon atoms or a valency bond; L stands for a lower alkyl group having 1 to 3 carbon atoms; and Z stands for a carboxyl group or a group convertible to carboxyl group, are useful as, for example, remedies for hyperlipemia, diabetes and so on of mammals including human beings.

.alpha.-Chlorocarboxylic acids

Compounds of the formula: ##STR1## wherein R.sup.1 represents hydrogen, lower alkyl having 1 to 5 carbon atoms, halogen, hydroxyl, lower alkoxy having 1 to 4 carbon atoms or trifluoromethyl; R.sup.2 and R.sup.3 are the same or different and each represents hydrogen or a lower alkyl having 1 to 5 carbon atoms; Y represents an alkylenethio group having 1 to 6 carbon atoms, alkyleneoxy having 1 to 6 carbon atoms, or alkylenedioxy having 1 to 6 carbon atoms; Z represents a carboxyl group or a group convertible to carboxyl and n is 1 or 2. The compounds have utility in treatment of hyperlipemia and diabetes.

2-Halopropionic acid and its derivatives

1,1-Dichloro-1a, 10b-dihydrodibenzo(b,f)cycloprop(d)azepine-6(1H)-carboxaldehyde is produced in good yield through a reaction between a compound of the general formula ##SPC1## Wherein R stands for hydrogen or formyl group and chloroform. Thus obtained product can be used as a valuable intermediate for synthesizing medicines and is further convertible to known drugs, e.g. 6-(3-dimethylamino)propyl)-1, 1a, 6, 10b-tetrahydrodibenzo(b,f)cycloprop(d)azepine.

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Osaka, Japan

Takahiro Saraie