Aska Pharmaceutical Co., Ltd.

Takahiro Nishimoto

Makoto Okada

Takashi Nose

Satoshi Maeda

Tomoji Aotsuka

Hashime Kanazawa

Youichi Nakano

Koichi Hasumi

Kouki Ishitani

Miwa Yoshida

A compound represented by the formula (1), or a salt thereof (X represents carbonyl group, or sulfonyl group; Rrepresents hydrogen atom, a halogen atom, an alkyl group, an alkanoyl group, cyano group, or carboxyl group; Rrepresents an alkyl group, a cyclic carbon group, or a heterocyclic group; Rrepresents hydrogen atom, or 1 to 3 substituents; Rand Rrepresents hydrogen atom, a halogen atom, or an alkyl group; and Rrepresents an alkyl group, or an alkoxy group), which has an mPGES-1 inhibitory action, and is useful as an active ingredient of a medicament for prophylactic and/or therapeutic treatment of inflammation, pain, rheumatism, and the like. 

Pyrimidine derivative

A heterocyclic compound useful as an antiallergic agent is provided. A compound represented by the following formula (1) or a salt thereof: 

Heterocyclic compound and H1 receptor antagonist

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Kanagawa, Japan

Takahiro Nishimoto