Morishita Jintan Co., Ltd.

Bioleaders Corporation

Genedesign, Inc.

Anges, Inc.

Takahiro Nakazawa

Ryuichi Morishita

Satoshi Inoue

Takashi Nomura

Takashi Miyake

Il-Han Lee

Akiko Temma

Tetsuo Miyake

Makoto Sakaguchi

Ryoji Ueki

Disclosed is a double-stranded oligonucleotide decoy including two transcription factor-binding sites, while keeping its size small. The double-stranded oligonucleotide decoy showing binding affinities for two transcription factors includes a first binding site for a first transcription factor and a second binding site for a second transcription factor. A first strand including the sense strand of the first binding site and a second strand including the sense strand of the second binding site are hybridized to form a double strand in which the sense strand of the first binding site and the sense strand of the second binding site are at least partly hybridized.

Chimeric decoy

An oral preparation for the prophylaxis or treatment of a disease with infection by a pathogen, containing a killed lactic acid bacterium expressing, on the surface, an antigen of the pathogen, or a microparticulated form thereof, which has an average particle size of 2.68-30 &#x3bc;m. An oral preparation for inducing cellular immunity to a target antigen, containing a killed lactic acid bacterium expressing the target antigen on the surface or a microparticulated form thereof, which has a particle size of 2.68-30 &#x3bc;m.

Oral vaccine having improved cellular immunity induction potency

Growing community of inventors

Osaka, Japan

Takahiro Nakazawa