Hamamatsu-photonics K.k.

Kyoto University

National Institute of Radiological Sciences

Takahiro Moriya

Motohiro Suyama

Tetsuo Kobayashi

Akinori Saito

Takenori Oida

Mitsuo Watanabe

Tomohide Omura

Kenshi Fukumitsu

Taiga Yamaya

Takaji Yamashita

Hideo Murayama

Naoko Inadama

Makoto Kakegawa

A brain measurement apparatus includes: a static magnetic field forming unit for forming a static magnetic field in a measurement area; a gradient magnetic field coil for forming a gradient magnetic field in the measurement area; a transmission coil for transmitting a transmission pulse toward a subject in the measurement area; a detection coil for detecting a nuclear magnetic resonance signal generated in the subject by transmission of the transmission pulse; and a generator for generating an MR image based on the nuclear magnetic resonance signal detected by the detection coil.

Brain measurement apparatus

A brain measurement apparatus configured to generate an MR image and a brain's magnetic field distribution of a subject includes: an MRI module having a transmission coil configured to transmit a transmission pulse toward the subject and a detection coil configured to detect a nuclear magnetic resonance signal generated in the subject by the transmission pulse; an optically pumped magnetometer configured to detect a brain's magnetic field of the subject; a generator configured to generate the MR image based on the nuclear magnetic resonance signal detected by the detection coil and generating the brain's magnetic field distribution based on the brain's magnetic field detected by the optically pumped magnetometer; a marker displayed on the MR image generated by the generator; and a helmet-type frame to which the detection coil, the optically pumped magnetometer, and the marker are attached and which is attached to a head of the subject.

Brain measurement apparatus and brain measurement method

A brain measurement apparatus includes: a magnetoencephalograph including optically pumped magnetometers, magnetic sensors for measuring geomagnetic field at positions of the optically pumped magnetometers, magnetic sensors for measuring a fluctuating magnetic field at the positions of the optically pumped magnetometers, nulling coils for cancelling the geomagnetic field, and an active shield coil for cancelling the fluctuating magnetic field; an MRI apparatus including nulling coils for applying a static magnetic field and a gradient magnetic field, a transmission coil, and a receive coil; and a control device that, when measuring a brain's magnetic field, controls currents supplied to the nulling coils and the active shield coil based on measured values of the magnetic sensors and, when measuring an MR image, controls the static magnetic field and the gradient magnetic field by controlling currents supplied to the nulling coils and generates an MR image from an output of the receive coil.

A brain measurement apparatus includes: a magnetoencephalograph including optically pumped magnetometers, magnetic sensors for measuring a static magnetic field at positions of the optically pumped magnetometers, and a nulling coil for canceling the static magnetic field; an MRI apparatus including a permanent magnet, a gradient magnetic field coil, a transmission coil, and a receive coil for detecting a nuclear magnetic resonance signal; and a control device that, when measuring the brain's magnetic field, controls a current to be supplied to the nulling coil based on measured values of the magnetic sensors and operates so as to cancel a static magnetic field at the position of each of the optically pumped magnetometers and, when measuring an MR image, controls the gradient magnetic field by controlling a current to be supplied to the gradient magnetic field coil and generates an MR image based on an output of the receive coil.

Provided is a brain measurement system including: a geomagnetic correction coil; a geomagnetic gradient correction coil; a transmission coil; a receiving coil; a plurality of resonance adjustment circuits; a plurality of OPM modules provided corresponding to each of the plurality of resonance adjustment circuits for detecting a signal having a resonance frequency output from the resonance adjustment circuit; and a control device for generating an MR image based on the signal detected by the OPM module, wherein, when a direction parallel to a central axis of a head portion of a subject is defined as a Z-axis direction, the resonance frequency related to each of the plurality of resonance adjustment circuits is set according to a magnetic field gradient in the Z-axis direction generated by control of a position of the corresponding receiving coil in the Z-axis direction and a tilted magnetic field.

Brain measurement system

An optically pumped magnetometer includes cells configured to form a first cell region and a second cell region on a measurement target, a pump laser, a probe laser, a first optical system configured to cause pump light to be incident on the first cell region, a second optical system configured to cause the pump light having passed through the first cell region to be incident on the second cell region, a third optical system configured to cause first probe light to be incident on the first cell region, a fourth optical system configured to cause second probe light to be incident on the second cell region, detection portions configured to detect the first probe light having passed through the first cell region and the second probe light having passed through the second cell region, and a deriving portion configured to derive an intensity of a magnetic field.

Optically pumped magnetometer having lasers and optical systems used to derive an intensity of a magnetic field

An optically pumped magnetometerincludes: a cell; a pump laserthat emits pump light; one or more pump light mirrors that cause the pump light guided in a first direction; a probe laserthat emits probe light; a splitting unitthat splits the probe light into multiple light components; one or more probe light mirrors that cause each of the probe light components guided in a second direction, which is a direction perpendicular to the first direction; a detection unit that detects each of the probe light components perpendicular to the pump light inside the cell; and a derivation unit that derives a magnetic field corresponding to a region where each of the probe light components and the pump light are perpendicular to each other based on a detection result of the detection unit.

Optically pumped magnetometer having reduced footprint

A magnetoencephalograph Mincludes: multiple pump-probe type optically pumped magnetometersA; a bias magnetic field forming coilfor applying a bias magnetic field in the same direction as a direction of pump light of each of the multiple pump-probe type optically pumped magnetometersA and in a direction approximately parallel to a scalp; a control devicethat determines a current for the bias magnetic field forming coil and outputs a control signal corresponding to the determined current; and a coil power supplythat outputs a current to the bias magnetic field forming coil in response to the control signal output from the control device.

Magnetoencephalograph

A PET device includes detectors including detector signal processing units and a data processing circuit configured to acquire a gamma ray generation position. The detector signal processing unit includes a Compton cone estimating unit configured to estimate incidence directions of gamma rays detected by a pair of detectors as a first and second Compton cones. The data processing unit includes: a coincidence acquiring unit; a scattering surface estimating unit; an intersection line determining unit; an intersection point determining unit; and a gamma ray generation position.

PET device and method of acquiring gamma ray generation position using scattered coincidence with PET device

A three-dimensional position-sensitive radiation detector is provided which has a three-dimensional array of photodetectors disposed on the surface of a scintillator block and which is capable of three-dimensionally identifying the position of light emission at which radiation has been detected within the detector. The three-dimensional position-sensitive radiation detector includes: a scintillator block including a central portion which restricts the direction of diffusion of light so as to direct the light in three axial directions and which has an optically discontinuous region, and an outer portion which is disposed on the outside of the central portion and which does not restrict the direction of diffusion of light; and photodetectors disposed on at least two outer circumferential surfaces of the scintillator block. The detector identifies three-dimensionally the position of light emission, thereby preventing deterioration in position discrimination performance even when inner scintillator elements are smaller than the photodetectors.

Three-dimensional position-sensitive radiation detector and method of identifying radiation detected positions therein

A radiation detector is provided with a scintillatorA containing a plurality of modified regionsand a plurality of photodetectors or a position-sensitive photodetector optically coupled to a surface of the scintillatorA. The plurality of modified regionsare formed by irradiating an inside of a crystalline lump which will act as the scintillatorA with a laser beam and three-dimensionally dotted and have a refractive index different from a refractive index of a surrounding region within the inside of the scintillatorA.

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Hamamatsu, Japan

Takahiro Moriya