Astellas Pharma Gmbh

Takahiro Miyazaki

Koji Kato

Hiroshi Nagata

Noriyuki Kawano

Kazuhiro Yokoyama

Naoyuki Masuda

Tadashi Terasaka

Toru Kontani

Hiroshi Inami

To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like. An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C-Calkylene, R: phenyl which may be substituted, etc., R: &#x2014;H or C-Calkyl, R: &#x2014;H, C-Calkyl or C-Ccycloalkyl, R: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].

Acylaminopiperidine compound

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Osaka, Japan

Takahiro Miyazaki