Fujisawa Pharmaceutical Company, Ltd.

Takahiro Matsuya

Hiroshi Matsuda

Keiji Matsuda

Kenji Murano

David Barrett

Takashi Ogino

Hidenori Ohki

Hiroaki Mizuno

Takashi Tojo

Nobuyuki Shiraishi

Kohji Kawabata

Norio Hashimoto

Ayako Toda

Atsushi Kanda

Masaharu Ichihara

Atsushi Ohigashi

This invention relates to new polypeptide compound represented by the general formula (I) wherein R, R, R, R, Rand Rare as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &#x3b2;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases includinginfection (e.g.pneumonia) in a human being or an animal.

Cyclic hexapeptide derivatives

This invention relates to new polypeptide compound represented by general formula (I), wherein R, R, R, R, Rand Rare as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &#x3b2;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases includinginfection (e.g.pneumonia) in a human being or an animal.

Cyclic hexapeptides having antibiotic activity

This invention relates to new polypeptide compounds represented by general formula (I), wherein R,, R,, R,and R,are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on &bgr;-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including,infection (e.g.,pneumonia) in a human being or an animal.

Cyclic hexapeptides with antimicrobial activity

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Osaka, Japan

Takahiro Matsuya