Terumo Kabushiki Kaisha

Terumo Corporation

Takahiro Kumonaka

Toshio Wakabayashi

Yasushi Suwabe

Kazuhiro Omori

Makoto Takai

Shinji Ozawa

Shigeru Taguchi

Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned 1-[2-(5-(3-methoxy-4-benzyloxyphenyl)-2,4-pentadienoyl)aminoethyl]-4-diphe nylmethoxypiperidine, 1-[2-(5-(3-methoxy-4-pentadienoyl)aminoethyl]-4-diphenylmethoxypiperidine and 1-[2-(5-(3-methoxy-4-ethoxymethoxyphenyl)-2,4-pentadienoyl)aminoethyl]-4-d iphenylmethoxypiperidine. These amide derivatives are useful as antiallergic agents.

Amide derivatives and antiallergic agents containing the same

Novel nitrate derivatives are disclosed. As examples of said nitrate derivative are described N-(.beta.-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)2,4-pentadienoic acid amide nitrate, N-(.beta.-hydroxyethyl)-3,4,5-trimethoxycinnamic acid amide nitrate and the like. These nitrate derivatives are useful as vasodilators.

Nitrate derivatives and vasodilators containing the same

There are disclosed novel piperazine derivatives and vasodilators containing the same. The compounds are useful for controlling or preventing vascular disorders such as cerebral embolism, myocardial infarction and limb arterial obstruction. As typical compounds are mentioned 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(pyrrolidinocarbonylmeth yl)-piperazine, 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(N-isopropylaminocarbony lmethyl)-piperazine, 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(N,N-dimethylaminocarbon ylmethyl)piperazine and 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(methylaminocarbonylmeth yl)-piperazine.

1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted

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Kawasaki, Japan

Takahiro Kumonaka