Hamamatsu-photonics K.k.

Massachusetts Institute of Technology

Pi Photonics, Inc.

Takahiro Ikeda

Norikazu Sugiyama

Takuji Kataoka

Michael S Feld

Gabriel Popescu

Ramachandra Rac Dasari

Tamiki Takemori

Toyohiko Yamauchi

Hidenao Iwai

Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.

System and method for Hilbert phase imaging

A membrane potential change detection device is provided with a reflection interference measurement light source, a holder which holds a transparent member on which cells are mounted, a reflection interference detection camera which images light emitted from the reflection interference measurement light source and reflected from the cells through the transparent member, to generate a reflection interference image, and an analysis unit which calculates a parameter dI about adhesion between the cells and the transparent member from the reflection interference image and detects a change of membrane potential of the cells on the basis of a change of the parameter dI.

Membrane potential change detection device and membrane potential change detection method

A cell observation device is provided with a reflection interference shutterA which adjusts a light quantity of light emitted from a reflection interference measurement light source, a quantitative phase shutterA which adjusts a light quantity of light emitted from a quantitative phase measurement light source, a camerawhich images reflected light from the reflection interference measurement light sourceto generate a reflection interference image and which images transmitted light from a quantitative phase measurement light sourceto generate a quantitative phase image, and a first extraction unitand a second extraction unitwhich extract first and second parameters from the reflection interference image generated by the camera. During generation of the reflection interference image, the quantitative phase shutterA blocks the light from the quantitative phase measurement light source. During generation of the quantitative phase image, the reflection interference shutterA blocks the light from the reflection interference measurement light source

Cell observation device and cell observation method

A cell stethoscopecomprises a sample image input sectionfor inputting image information of a cell, an image display partfor displaying the image information to an observer, an area designation partfor designating a fixed area included in the image information in response to an operation carried out by the observer according to the image information displayed by the image display part, a frequency conversion sectionfor frequency-converting vibration information of the cell in the fixed area designated by the area designation partinto sound information, and a sound output partfor outputting the sound information frequency-converted by the frequency conversion sectionto the observer.

Sample identification device and sample identification method

A cell observation device is provided with a reflection interference measurement light source, a quantitative phase measurement light source, a reflection interference detection camerawhich images light emitted from the reflection interference measurement light sourceand reflected from cells, to generate a reflection interference image, a quantitative phase detection camerawhich images light emitted from the quantitative phase measurement light sourceand transmitted by the cells, to generate a quantitative phase image, an image alignment unitwhich matches a spatial position of the reflection interference image with a spatial position of the quantitative phase image, to implement alignment between the two images, a first extraction unitwhich extracts a first parameter from the reflection interference image in alignment with the quantitative phase image, and a second extraction unitwhich extracts a second parameter from the quantitative phase image in alignment with the reflection interference image.

The present invention is capable of irradiating a desired figure, a character and the like onto an object with a simple configuration and further capable of easily changing the figure, the character and the like, and includes an LED light source, a first refractive element adapted to refract light emitted from the LED light source to form an image of a light emitting shape when viewed in an optical axis direction of the LED light source at a predetermined position and a casing accommodating the LED light source and the first refractive element and having a light outgoing aperture for emitting the light applied from the first refractive element to the outside.

Lighting device for forming pattern

A three-dimensional image displaying apparatus comprises a spatial light modulation element having a discrete pixel structure and expressing a hologram, an illumination optical system generating reconstruction light by causing illumination light to enter said spatial light modulation element that expresses the hologram, and a lens as a reconstruction image converting optical system displaying a reconstruction image by producing a virtual image wavefront-converted from the reconstruction light.

Three-dimensional image display and three-dimensional image displaying method

A small, inexpensive three-dimensional image display having a structure for displaying a color three-dimensional image sharply even if a low-resolution spatial optical modulating element is used. The three-dimensional image display has an illumination light source unit, a transmission spatial optical modulating element, a lens, and a mask. The illumination light source unit includes three point light sources outputting illumination light components having wavelengths (red, green, blue) different from one another. The point light source outputting the blue illumination light component of the shortest wavelength is disposed in position B() on the optical axis of an illumination optical system, the point light source outputting the red illumination light component is disposed in position R(x), and the point light source outputting the green illumination light component is disposed in position G(x). An aperture section of the mask is disposed in the region where the zero-order diffracted waves of the reproduction light components of the three wavelengths after subjected to wavefront conversion by the lens are superposed on one another. The illumination optical system determines the direction of incidence of each of the illumination optical components of the three wavelengths on the spatial optical modulation element.

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Hamamatsu, Japan

Takahiro Ikeda