Seikagaku Corporation

Takahiro Hatanaka

Yuko Yoshida

Sho Funayama

Risa Nodera

Muneto Narita

Yasuhiro Goto

Tomochika Kisukeda

Yuichi Chikaraishi

Provided are a composition comprising a GAG derivative and a chemokine receptor activity regulator, and a pharmaceutical composition comprising said composition.

Composition including glycosaminoglycan derivative and chemokine receptor activity regulator

Provided is a chondroitin sulfate derivative having a cross-linked structure through a group in a polyvalent amine. Also provided is a composition containing the chondroitin sulfate derivative. Also provided are an agent and method for the treatment of an eye disease, the agent and method having a therapeutic effect on a corneal epithelial disorder and/or dry eye.

Crosslinked chondroitin sulfate, composition containing same, and treatment agent for eye disease

A compound includes a group derived from chondroitin sulfate, a group derived from a steroid, and a spacer. The group derived from the chondroitin sulfate and the group derived from the steroid are covalently bonded together via the spacer, and a spacer forming molecule of the spacer is &#x3b2;-alanine or isoleucine. A covalent bond between the group derived from the steroid and the spacer is an ester bond, and a covalent bond between the group derived from the chondroitin sulfate and the spacer is an amide bond. The steroid is at least one selected from the group consisting of prednisolone, betamethasone, triamcinolone, triamcinolone acetonide, budesonide and fluticasone.

Chondroitin sulfate derivative and agent for treating bladder diseases

Provided is a compound in which a group derived from chondroitin sulfate and a group derived from a steroid are covalently bonded together via a spacer represented by general formula (I). In the formula, m represents an integer of 0 or 1. Here, if m=0, Rrepresents a group selected from the group consisting of electron-donating groups and steric hindrance groups. If m=1, Rrepresents a group selected from the group consisting of a hydrogen atom, electron-donating groups and steric hindrance groups.&#x2014;HN&#x2014;(CH)&#x2014;CHR&#x2014;CO&#x2014;&#x2003;&#x2003;(I)

Growing community of inventors

Tokyo, Japan

Takahiro Hatanaka