Banyu Pharmaceutical Co. Ltd

Other

Merck + Co., Inc.

Takahiro Fukuroda

Akio Kanatani

Takehiro Fukami

Masaki Ihara

Lihu Yang

Ying-Duo Gao

Douglas J MacNeil

Yasuyuki Ishii

Nancy R Morin

Masaru Nishikibe

Kazuo Kamei

Jun Nagura

Toshiaki Mase

Yoshimi Tsuchiya

Takayoshi Okabe

Spiro-indolines as Y5 receptor antagonists

NPY Y5 receptor antagonists

Compounds of general structural formula I such as that shown in structural formula II

The present invention relates to a neuropeptide Y receptor antagonist comprising a compound represented by the formula &lsqb;I&rsqb;:

Neuropeptide Y receptor antagonist

Compounds of the general structural formula I

The present invention relates to a compound represented by the general formula &lsqb;I&rsqb;:

Aminopyrazole derivatives

The present invention relates to a compound represented by the general formula [I]: ##STR1## wherein A and B rings are ortho-condensed to each other, A ring represents an aromatic carbocyclic or heterocyclic ring and B ring represents an aliphatic four- to seven-membered carbocyclic or nitrogen-containing heterocyclic ring, said nitrogen atom being possible to present at only the position where the A ring is condensed; Ar represents an aromatic carbocyclic or heterocyclic ring group which may have a substituent selected from the group consisting of a halogen atom and lower alkyl, lower alkenyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower alkylamino, lower dialkylamino and aromatic carbocyclic ring groups; and R represents a substituent selected from the group consisting of a halogen atom and nitro, lower alkyl, lower alkoxy, aromatic carbocyclic ring groups and a carbonyl group having an aromatic carbocyclic ring group, or a hydrogen atom, provided that when the group represented by ##STR2## is the group represented by ##STR3## Ar is not a phenyl group nor a 4-chlorophenyl group, or its salt, a method for its preparation as well as an agent for the treatment of bulimia, obesity or diabetes comprising it as an active ingredient.

Pyrazole derivatives

Urea derivatives

Aminopyridine derivatives

An ameliorant of cerebral circulation which contains 2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3 ,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester as an active ingredient.

Method of ameliorating cerebral circulation

An ameliorant of cerebral circulation which contains 2-carbamoyloxymethyl-4-(2,3-dichlorophenyl )-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-isopropyl ester 5-methyl ester as an active ingredient.

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Tsukuba, Japan

Takahiro Fukuroda